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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Papillary Dermis01:11

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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
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Cells of the Epidermis01:24

Cells of the Epidermis

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The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
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Pigmentation01:19

Pigmentation

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The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
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Accessory Structures of the Skin: Sebaceous Glands01:21

Accessory Structures of the Skin: Sebaceous Glands

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A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
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Accessory Structures of the Skin: Sweat Glands01:20

Accessory Structures of the Skin: Sweat Glands

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Sweat glands or sudoriferous glands are one of the important accessory structures of the skin. They are small, coiled tubular structures located in the dermis, the middle layer of the skin. Sweat glands are responsible for producing and secreting sweat, a watery fluid that helps regulate body temperature and excrete waste products.
Sweat glands are classified as merocrine glands; that is, the secretions are excreted by exocytosis through a duct without affecting the cells of the gland. There...
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Related Experiment Video

Updated: Feb 19, 2026

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
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Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

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Eccrine-Centric Melanocytic Nevus.

Raymond M Fertig1, Adar Berghoff2, Jessica Cervantes1

  • 1Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL.

The American Journal of Dermatopathology
|November 3, 2017
PubMed
Summary
This summary is machine-generated.

A novel benign melanocytic nevus pattern, the eccrine-centric melanocytic nevus, is described. This rare presentation mimics metastatic disease, emphasizing the need for accurate histopathologic diagnosis in pigmented lesions.

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Area of Science:

  • Dermatopathology
  • Histopathology
  • Oncology

Background:

  • Benign melanocytic neoplasms exhibit diverse histopathologic patterns.
  • Accurate diagnosis relies on recognizing these patterns.
  • Distinguishing benign from malignant pigmented lesions is crucial.

Observation:

  • A 50-year-old African American woman presented with a rapidly growing mole on her foot.
  • Histopathologic examination revealed a unique pattern of melanocytic nevus.
  • The lesion displayed increased eccrine gland density with melanocytes exclusively in a peri-eccrine distribution.

Findings:

  • The described lesion is an eccrine-centric melanocytic nevus, a previously unreported low-power architectural pattern.
  • Melanocytes were densely pigmented and located solely around eccrine gland ducts.
  • No atypical features suggestive of malignancy were observed.

Implications:

  • This distinctive pattern, while benign, can be mistaken for metastatic disease due to well-delineated dermal nests.
  • Recognition of this eccrine-centric pattern is vital for accurate diagnosis and avoiding misclassification.
  • Understanding rare melanocytic nevus presentations enhances diagnostic capabilities in pigmented lesion evaluation.