Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intraoperative Zoledronic Acid for Arthroscopic Rotator Cuff Repair Results in Distinct Circulating Micro-RNA Profiles Indicating Improved Tendon-to-Bone Healing.

The American journal of sports medicine·2026
Same author

Injectable Hydrogel-Based Delivery of Soluble Cripto Protein Enhances Repair After Skeletal Muscle Injury.

ACS biomaterials science & engineering·2026
Same author

Transcription-independent induction of rapid-onset senescence is integral to healing.

Nature cell biology·2026
Same author

Interaction of pulsed low frequency electromagnetic field (PEMF) with mitochondria.

Scientific reports·2026
Same author

Intraoperative Zoledronic Acid for Arthroscopic Rotator Cuff Repair: Short-Term Results From a Prospective, Randomized, Placebo-Controlled Phase II Trial.

The American journal of sports medicine·2026
Same author

Femtosecond Laser Engraving Promotes the Repopulation of Decellularized Human Articular Cartilage.

Journal of tissue engineering and regenerative medicine·2026

Related Experiment Video

Updated: Feb 19, 2026

Preparation and Characterization of Graphene-Based 3D Biohybrid Hydrogel Bioink for Peripheral Neuroengineering
10:17

Preparation and Characterization of Graphene-Based 3D Biohybrid Hydrogel Bioink for Peripheral Neuroengineering

Published on: May 16, 2022

2.8K

Hydrogel composition and laser micropatterning to regulate sciatic nerve regeneration.

Yulia Berkovitch1,2, Talia Cohen3, Eli Peled3,4

  • 1The Faculty of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa, Israel.

Journal of Tissue Engineering and Regenerative Medicine
|November 3, 2017
PubMed
Summary
This summary is machine-generated.

Advanced hydrogels with microchannels promote nerve regeneration in rats. Tailored stiffness and degradation are key for effective peripheral nerve repair and tissue growth.

Keywords:
biomaterialsfibrinogenhydrogelsmicropatterningnerve guidance conduitnerve regeneration

More Related Videos

Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation
09:19

Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation

Published on: December 8, 2017

15.7K
Development of Combinatorial Therapeutics for Spinal Cord Injury using Stem Cell Delivery
05:13

Development of Combinatorial Therapeutics for Spinal Cord Injury using Stem Cell Delivery

Published on: June 7, 2024

531

Related Experiment Videos

Last Updated: Feb 19, 2026

Preparation and Characterization of Graphene-Based 3D Biohybrid Hydrogel Bioink for Peripheral Neuroengineering
10:17

Preparation and Characterization of Graphene-Based 3D Biohybrid Hydrogel Bioink for Peripheral Neuroengineering

Published on: May 16, 2022

2.8K
Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation
09:19

Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation

Published on: December 8, 2017

15.7K
Development of Combinatorial Therapeutics for Spinal Cord Injury using Stem Cell Delivery
05:13

Development of Combinatorial Therapeutics for Spinal Cord Injury using Stem Cell Delivery

Published on: June 7, 2024

531

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Neuroscience

Background:

  • Peripheral nerve injuries require advanced treatments for effective regeneration.
  • Sophisticated materials with trophic and topographical cues are essential for nerve repair.
  • Hydrogels offer a promising platform for guided nerve regeneration.

Purpose of the Study:

  • To explore advanced hydrogel designs for peripheral nerve repair.
  • To investigate the role of microchannel patterning in nerve regeneration.
  • To evaluate the impact of material properties on neuron and glial cell regeneration.

Main Methods:

  • Utilized fibrin, polyethylene glycol-fibrinogen, and gelatin hydrogels.
  • Applied photo-patterning to create laser-ablated microchannels for contact guidance.
  • Tested regeneration in a rat sciatic nerve resection model with varying hydrogel properties (stiffness, composition, micropatterning).

Main Results:

  • Photo-patterned hydrogels with microchannels significantly enhanced nerve regeneration.
  • Optimal material stiffness and degradation properties were crucial for uniform tissue propagation.
  • Microchannel guidance, combined with matched material properties, proved essential for successful nerve repair.

Conclusions:

  • Advanced hydrogel biomaterials with microchannel guidance facilitate peripheral nerve regeneration.
  • Material properties like stiffness and degradation rate must be carefully matched for optimal outcomes.
  • This strategy shows potential for improving treatments for peripheral nerve injuries.