Lipoprotein apheresis influences monocyte subpopulations
S Jellinghaus1, C Reich1, U Schatz2
1Internal Medicine and Cardiology, Heart Center Dresden, University Hospital at the Technische Universität, Dresden, Germany.
Atherosclerosis. Supplements
|November 4, 2017
Summary
Lipoprotein apheresis (LA) influences monocyte subpopulations, increasing classical and decreasing non-classical monocytes. The specific LA method impacts these changes, with intermediate monocytes remaining largely unaffected.
Area of Science:
- Immunology
- Cardiovascular Medicine
- Hematology
Background:
- Monocytes differentiate into subpopulations based on CD14 and CD16 expression.
- CD16-positive monocytes are linked to coronary artery disease.
- The effect of lipoprotein apheresis (LA) on monocyte subpopulations is currently unknown.
Purpose of the Study:
- To investigate the impact of lipoprotein apheresis (LA) on the distribution of monocyte subpopulations.
- To determine if different LA methods have varying effects on monocyte populations.
Main Methods:
- Analysis of 80 patients undergoing LA using six different methods.
- Blood samples collected pre- and post-LA analyzed for CD14 and CD16 monocyte expression.
- Comparison with a control group of 42 patients with cardiovascular risk factors.
Main Results:
- LA increased classical monocytes (CD14++CD16-) and decreased non-classical monocytes (CD14+CD16+).
- Intermediate monocytes (CD14++CD16+) showed no significant change after LA.
- Specific methods (MONET, Therasorb® LDL) did not alter monocyte distribution; high LDL-C pre-LA correlated with increased intermediate monocytes.
Conclusions:
- Lipoprotein apheresis influences monocyte subpopulation distribution, with effects varying by LA method.
- Classical and non-classical monocyte content is primarily affected by LA.
- Intermediate monocyte populations remain largely unaltered by LA.
