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Microbiota and Breast Cancer.

Sridhar Mani1

  • 1Albert Einstein College of Medicine INC, Bronx, NY, United States.

Progress in Molecular Biology and Translational Science
|November 4, 2017
PubMed
Summary

The human microbiota, specifically bacteria, significantly influences breast cancer development and drug response. Understanding these bacterial roles is crucial for advancing breast cancer research and treatment strategies.

Area of Science:

  • Microbiology
  • Oncology
  • Human Microbiome Research

Background:

  • Breast cancer etiology is multifactorial, with environmental influences, particularly the microbiota, being under-characterized.
  • The human microbiota, defined here as bacterial microbes, plays a role in distant environmental influences on health.
  • Specific bacterial communities within the body may impact breast cancer initiation, progression, and treatment outcomes.

Purpose of the Study:

  • To identify and describe pathways linking bacterial influences to breast cancer.
  • To explore how bacteria contribute to breast cancer priming, maintenance of malignancy, and drug sensitivity.
  • To present preliminary conclusions on the role of specific bacteria in breast carcinogenesis.

Main Methods:

  • Review and synthesis of published data on bacterial influences in breast cancer.
Keywords:
breast cancerestrogenintestinalmetabolitesmicrobiome

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  • Identification of key bacterial locations: breast tissue, skin, oropharynx, and gastrointestinal tract.
  • Analysis of pathways connecting bacterial activity to cancer development and drug response.

    • Main Results:

    • Bacteria residing in various body sites, including breast tissue and the gut, exert significant influence on breast cancer.
    • Specific bacterial pathways have been identified that may prime the breast for cancer or maintain a malignant state.
    • Bacterial presence and activity can modulate the sensitivity of breast cancer to therapeutic drugs.

    Conclusions:

    • The human microbiota, particularly bacterial communities, is an important factor in breast carcinogenesis and cancer progression.
    • Understanding the specific contributions of different bacteria offers potential new avenues for breast cancer prevention and therapy.
    • Further research into the complex interactions between bacteria and breast cancer is warranted to elucidate precise mechanisms and therapeutic targets.