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Updated: Feb 19, 2026

Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK

Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK

Published on: December 18, 2012

Infectious crystalline keratopathy.

Ashley J Porter¹, Graham A Lee², Albert S Jun³

¹City Eye Centre, Brisbane, Queensland, Australia.

Survey of Ophthalmology

|November 4, 2017

Summary

This summary is machine-generated.

Infectious crystalline keratopathy, a bacterial cornea infection post-surgery, presents as a branching opacity. Treatment involves antimicrobials, biofilm disruption, and sometimes corneal transplantation.

Keywords:

biofilm infectious crystalline keratopathy keratitis keratoplasty

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Area of Science:

Ophthalmology
Microbiology

Background:

Infectious crystalline keratopathy (ICK) is a rare corneal infection.
First described in 1983, it typically occurs after penetrating keratoplasty.
Characterized by a stromal opacity and minimal inflammation due to local immunosuppression.

Purpose of the Study:

To review the etiology, diagnosis, and management of infectious crystalline keratopathy.
To highlight challenges in pathogen identification and treatment efficacy.

Main Methods:

Literature review of infectious crystalline keratopathy cases.
Analysis of diagnostic difficulties, including biofilm interference.
Summary of treatment strategies, from topical antimicrobials to surgical interventions.

Main Results:

ICK presents as a branching opacity from an epithelial defect, often post-keratoplasty.
Bacterial biofilms complicate diagnosis and reduce antibiotic effectiveness.
Effective treatment requires targeted antimicrobials and may involve biofilm disruption or keratectomy.

Conclusions:

Prompt and appropriate management is crucial for favorable outcomes in ICK.
Addressing the microbial biofilm is key to successful treatment.
Corneal transplantation remains an option for severe or refractory cases.