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1',2'-seco-dideoxynucleosides as potential anti-HIV agents

E Abushanab¹, M S Sarma

¹Department of Medicinal Chemistry, University of Rhode Island, Kingston 02118.

Journal of Medicinal Chemistry

|January 1, 1989

Abstract:

1',2'-seco-2',3'-Dideoxycytidine (12), -guanosine (14), -adenosine (16), and -inosine (18) were prepared from (R)-benzylglycidol as potential anti-HIV agents. When compared to ddAdo in protecting ATH8 cells, they were found to be inactive.

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