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Published on: August 31, 2022
Hepatic 18F-FDG Uptake Measurements on PET/MR: Impact of Volume of Interest Location on Repeatability
Liran Domachevsky1,2, Hanna Bernstine1,2, Meital Nidam1,2
1Department of Nuclear Medicine, Assuta Medical Centers, Tel Aviv, Israel.
Background:
To investigate same day 18F-FDG (Fluorodeoxyglucose) PET (Positron Emission Tomography)/MR (Magnetic Resonance) test-retest repeatability of Standardized Uptake Value measurements normalized for body weight (SUV) and lean body mass (SUL) in different locations in the liver.
Methods:
This prospective study was IRB approved with written informed consent obtained. 35 patients (20 women and 15 men, 61 ± 11.2 years) that performed a whole-body 18F-FDG PET/MR followed by liver-dedicated contrast-enhanced 18F-FDG PET/MR were included. SUV/L max, mean, and peak were measured inferior to, superior to, and at the right portal vein and in the left lobe of the liver. The coefficient of variation (CV) and intraclass correlation coefficient (ICC) were calculated and Bland-Altman plots were obtained.
Results:
The variability for SUV/L's measurements was lowest inferior to the portal vein (<9.2%) followed by measurements performed at the level of the portal vein (<14.6%).
Conclusion:
The area inferior to the portal vein is the most reliable location for hepatic 18F-FDG uptake measurements on PET/MR.
Insights
Repeatability of liver 18F-FDG PET/MR measurements was assessed. The area inferior to the portal vein showed the lowest variability for Standardized Uptake Value (SUV) and SUL measurements, indicating highest reliability.
Area of Science:
- Nuclear Medicine
- Radiology
- Medical Imaging
Background:
- Positron Emission Tomography/Magnetic Resonance (PET/MR) combines functional and anatomical imaging.
- 18F-FDG PET/MR is increasingly used for oncological staging and therapy response assessment.
- Standardized Uptake Value (SUV) and SUL measurements assess metabolic activity, but their repeatability in the liver requires investigation.
Purpose of the Study:
- To evaluate the test-retest repeatability of 18F-FDG PET/MR Standardized Uptake Value (SUV) and SUL measurements in different liver locations.
- To identify the most reliable region within the liver for quantitative 18F-FDG uptake assessment using PET/MR.
Main Methods:
- Prospective study involving 35 patients undergoing same-day whole-body and liver-dedicated 18F-FDG PET/MR.
- Measurements of SUV/L (max, mean, peak) were taken superior to, inferior to, and at the right portal vein, and in the left lobe.
- Repeatability was assessed using coefficient of variation (CV), intraclass correlation coefficient (ICC), and Bland-Altman plots.
Main Results:
- The lowest measurement variability for SUV/L was observed in the liver area inferior to the portal vein (CV <9.2%).
- Measurements at the level of the portal vein showed slightly higher variability (CV <14.6%).
- The left lobe and area superior to the portal vein exhibited greater variability.
Conclusions:
- The region inferior to the portal vein is the most reliable for hepatic 18F-FDG uptake measurements on PET/MR.
- This finding is crucial for accurate quantitative analysis and monitoring of liver lesions using 18F-FDG PET/MR.
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