Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

3.9K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.9K
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

289
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
289
Bone Disorders01:29

Bone Disorders

5.6K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.6K
Aging01:26

Aging

879
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
879
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

253
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
253
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

272
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
272

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Indigenous 2SLGBTQIA+ Identities and Age-Related Cognitive Decline: A Scoping Review.

International journal of environmental research and public health·2026
Same author

Sepsis policy, guidelines, and standards in Canada: a jurisdictional scoping review.

BMC health services research·2026
Same author

A qualitative study to create a framework of Métis understandings of brain health promotion and dementia prevention in Alberta, Canada.

Frontiers in dementia·2026
Same author

Basic Science and Pathogenesis.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Public Health.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Public Health.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025

Related Experiment Video

Updated: Feb 19, 2026

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
05:53

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty

Published on: July 24, 2013

17.1K

Aging and Frailty in First Nations Communities.

, Jennifer D Walker1

  • 1School of Rural and Northern Health, Laurentian University.

Canadian Journal on Aging = La Revue Canadienne Du Vieillissement
|November 4, 2017
PubMed
Summary

This study examined aging among First Nations seniors using the First Nations Regional Health Survey. Findings reveal a decline in non-frail status in middle-aged adults, underscoring the need for early health interventions.

Keywords:
First NationsPremières Nationsagingfragilitéfrailtysurveyvieillissementétude

More Related Videos

Frailty Assessment in an Aging Mouse Model
06:58

Frailty Assessment in an Aging Mouse Model

Published on: September 23, 2025

656
Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles
04:00

Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles

Published on: July 26, 2024

1.4K

Related Experiment Videos

Last Updated: Feb 19, 2026

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
05:53

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty

Published on: July 24, 2013

17.1K
Frailty Assessment in an Aging Mouse Model
06:58

Frailty Assessment in an Aging Mouse Model

Published on: September 23, 2025

656
Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles
04:00

Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles

Published on: July 26, 2024

1.4K

Area of Science:

  • Gerontology
  • Indigenous Health
  • Public Health

Background:

  • First Nations seniors represent a unique demographic with distinct health considerations.
  • Previous research has lacked a nationally representative overview of aging experiences within this population.
  • The application of a validated frailty index offers a novel approach to assessing aging in First Nations communities.

Purpose of the Study:

  • To provide the first nationally representative overview of aging among First Nations seniors.
  • To apply a validated frailty index to describe aging experiences in First Nations communities.
  • To identify trends in frailty status across different adult age groups within the First Nations population.

Main Methods:

  • Utilized data from the First Nations Regional Health Survey Phase 2 (FNRHS 2).
  • Included 1,820 First Nations seniors in the analysis.
  • Applied a validated frailty index to assess the health status of participants.

Main Results:

  • 52.7% of First Nations seniors were not frail.
  • Non-frail status decreased from 87.9% in ages 35-44 to 63.1% in ages 55-64.
  • Frailty status appeared to plateau after age 65.

Conclusions:

  • This study offers a crucial First Nations perspective on national aging experiences.
  • Findings highlight the necessity of early supportive health services and chronic disease management.
  • Interventions should be considered for middle-aged First Nations adults to promote healthy aging.