DEFINITION OF ETIOLOGICAL ANTIBIOTIC SENSITIVITY FACTORS IN PURULENT-INFLAMMATORY PROCESSES

Area of Science:

• Medical Microbiology
• Infectious Diseases
• Antimicrobial Resistance

Background:

• Purulent-inflammatory processes are significant clinical challenges.
• Identifying etiological factors and microbial agents is crucial for effective treatment.
• The role of microbial biofilms in treatment failure is increasingly recognized.

Purpose of the Study:

• To assess etiological factors of purulent-inflammatory processes.
• To determine the antibiotic sensitivity of planktonic and biofilm microbial agents.
• To investigate the prevalence of specific bacterial pathogens in clinical samples.

Main Methods:

• Isolation and identification of clinical microbial strains from patient samples (wound tissue, pus, etc.).
• Assessment of bacterial biofilm formation using polystyrene flatbeds.
• Determination of microbial isolate sensitivity to various antibiotics via micro-test systems.

Main Results:

• Staphylococcus aureus (36.5%) and E. coli (17.3%) were leading causes of purulent-inflammatory processes.
• Other significant pathogens included Proteus spp. (14.6%), S. pyogenes (12.8%), P. aeruginosa (6.9%), and K. pneumoniae (6.7%).
• All isolates formed dense biofilms, and most exhibited polyresistance to antibiotics in biofilm form, contrasting with higher sensitivity in planktonic form to agents like Cefepime and Imipenem.

Conclusions:

• Bacterial biofilms significantly contribute to antibiotic resistance in purulent-inflammatory processes.
• The widespread and often ineffective use of antimicrobials drives the emergence of multidrug-resistant strains.
• Targeted antibiotic strategies considering planktonic and biofilm sensitivities are essential for managing these infections.