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Mycardial ischemia and determined chaos in integral homeostatic regulation
L Sarayev1, V Dovgal, A Kuzmenko
1Department of Anaesthesiology, Kursk State Medical University, Russia.
Insights
This study reveals a new method to detect myocardial ischemia during stress tests. Analyzing cardiac rhythm entropy dynamics can identify subtle changes indicative of heart problems.
Area of Science:
- Cardiology
- Nonlinear dynamics
- Systems biology
Background:
- Homeostatic stability is crucial for cardiovascular health.
- Myocardial ischemia, often induced by stress, poses a significant health risk.
- Current stress testing methods can sometimes yield ambiguous results.
Purpose of the Study:
- To investigate homeostatic stability loss in patients with coronary heart disease during stress testing.
- To explore the application of cardiac rhythm entropy dynamics for evaluating the systemic homeokinetic state.
- To develop a novel method for quantifying cardiac rhythm entropy chaotisity.
Main Methods:
- Simultaneous bicycle ergometry and continuous cardiac-interval duration monitoring were performed.
- Cardiac rhythm entropy dynamics were analyzed in a multidimensional phase space.
- A new method for measuring cardiac rhythm entropy chaotisity level was developed and applied.
Main Results:
- Determined chaos was identified as a key property of cardiac rhythm dynamics in all subjects.
- A distinct phenomenon of sharp rise and subsequent decrease in cardiac entropy trajectory chaotisity was observed.
- This phenomenon occurred within the multidimensional phase space.
Conclusions:
- The observed changes in cardiac entropy trajectory chaotisity may serve as an additional criterion for myocardial ischemia.
- This finding could aid in verifying uncertain stress-testing results.
- The study introduces a novel approach to assess cardiovascular stability during exertion.
Abstract:
This study was devoted to the problem of homeostatic stability loss caused by myocardial ischemia, induced by stress testing. It involved 55 patients with different variants of coronary heart disease and 15 practically healthy volunteers as controls. Routine bicycle ergometry and nonstop monitoring of the cardiac-interval duration were conducted simultaneously. The systemic homeokinetic state was evaluated by means of cardiac rhythm entropy dynamics analysis in a multidimensional space of existence. Determined chaos was shown to be the main property of these dynamics in all cases. The original method of measuring the cardiac rhythm entropy chaotisity level is presented. It is suggested that the newly revealed phenomenon of a sharp rise in the cardiac entropy trajectory chaotisity level and followed by a decrease, which happens in the multidimensional phase space, may be used as an additional criterion of myocardial ischemia development for the verification of dubious stress-testing results.