Self-Emulsifying Granules and Pellets: Composition and Formation Mechanisms for Instant or Controlled Release

Area of Science:

• Pharmaceutical Sciences
• Drug Delivery Systems
• Materials Science

Background:

• Self-emulsifying drug delivery systems (SEDDS) enhance dissolution and absorption of poorly soluble drugs.
• Existing liquid/semisolid SEDDS face challenges like high cost, stability issues, and surfactant load.
• Solid SEDDS (S-SEDDS) offer a more stable and versatile alternative for drug formulation.

Purpose of the Study:

• To review materials, properties, and preparation of S-SEDDS.
• To discuss factors influencing S-SEDDS characteristics and performance.
• To elucidate mechanisms of S-SEDDS formation and drug release.

Main Methods:

• Literature review of S-SEDDS formulations from 2004-2017.
• Analysis of materials, physical characteristics, and mechanical properties of S-SEDDS.
• Examination of in vitro drug release and in vivo absorption data.

Main Results:

• S-SEDDS can be prepared as powders, granules, or pellets for easy processing into capsules or tablets.
• Formulation components significantly impact S-SEDDS properties, including re-emulsification and drug release.
• Relationships between S-SEDDS unit characteristics and submicron emulsion properties were elucidated.

Conclusions:

• S-SEDDS provide an advantageous solid dosage form for improving drug solubility and absorption.
• Understanding material properties and formulation parameters is crucial for optimizing S-SEDDS performance.
• S-SEDDS offer potential for both instant and controlled drug release applications.