Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Data-driven system identification in cancer systems biology: A multiscale modeling approach to melanoma.

Computer methods and programs in biomedicine·2026
Same author

Intrinsically disordered regions facilitate Mlp1-Nab2 recognition in mRNA quality control.

Nucleus (Austin, Tex.)·2026
Same author

On the state of protein function prediction: a report on the fourth CAFA challenge.

bioRxiv : the preprint server for biology·2026
Same author

Therapeutic embolic agents for targeted drug delivery in transcatheter therapies: a review.

Chemical communications (Cambridge, England)·2026
Same author

A dual-lumen microcatheter for minimizing particle reflux during embolization: Proof-of-concept with multiphysics simulations.

Computers in biology and medicine·2026
Same author

Genome modelling and design across all domains of life with Evo 2.

Nature·2026

Related Experiment Video

Updated: Feb 19, 2026

Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro
05:47

Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro

Published on: May 10, 2021

4.7K

A strain-based finite element model for calcification progression in aortic valves.

Amirhossein Arzani1, Mohammad R K Mofrad2

  • 1Mechanical Engineering Department, Northern Arizona University, Flagstaff, AZ, USA.

Journal of Biomechanics
|November 5, 2017
PubMed
Summary

Calcific aortic valve disease (CAVD) progression is linked to mechanical stress. A finite element model simulating cardiac cycles showed calcification expanding radially in high-strain areas, matching clinical observations.

Keywords:
Calcific aortic valve diseaseFinite element methodMechanical strainTransient structural mechanics

More Related Videos

Intravascular Ultrasound Image-Based Finite Element Modeling Approach for Quantifying In Vivo Mechanical Properties of Human Coronary Artery
06:18

Intravascular Ultrasound Image-Based Finite Element Modeling Approach for Quantifying In Vivo Mechanical Properties of Human Coronary Artery

Published on: December 6, 2024

1.1K
Isolation of Human Primary Valve Cells for In vitro Disease Modeling
07:31

Isolation of Human Primary Valve Cells for In vitro Disease Modeling

Published on: April 16, 2021

3.3K

Related Experiment Videos

Last Updated: Feb 19, 2026

Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro
05:47

Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro

Published on: May 10, 2021

4.7K
Intravascular Ultrasound Image-Based Finite Element Modeling Approach for Quantifying In Vivo Mechanical Properties of Human Coronary Artery
06:18

Intravascular Ultrasound Image-Based Finite Element Modeling Approach for Quantifying In Vivo Mechanical Properties of Human Coronary Artery

Published on: December 6, 2024

1.1K
Isolation of Human Primary Valve Cells for In vitro Disease Modeling
07:31

Isolation of Human Primary Valve Cells for In vitro Disease Modeling

Published on: April 16, 2021

3.3K

Area of Science:

  • Cardiovascular Research
  • Biomedical Engineering
  • Computational Biology

Background:

  • Calcific aortic valve disease (CAVD) is a prevalent condition in aging populations.
  • CAVD pathogenesis involves intricate interactions of biochemical factors, cellular activity, and mechanical forces.
  • Understanding the spatial progression of calcification is crucial for developing effective treatments.

Purpose of the Study:

  • To develop and validate a computational model for predicting the spatial progression of calcific aortic valve disease.
  • To investigate the correlation between mechanical strain and calcification deposition in the aortic valve.

Main Methods:

  • Utilized a finite element method (FEM) to create a spatial model of calcification progression.
  • Simulated multiple cardiac cycles using transient structural FEM analysis.
  • Incorporated calcium deposition in regions of high circumferential strain after each simulation cycle.

Main Results:

  • The model demonstrated radial expansion of calcification, appearing as 'spokes' originating from the valve's attachment region.
  • The simulated calcification patterns closely mirrored patterns observed in clinical data.
  • High circumferential strain was identified as a key driver for localized calcium deposition.

Conclusions:

  • The developed FEM-based model effectively simulates the spatial progression of calcific aortic valve disease.
  • Mechanical strain, particularly circumferential strain, plays a significant role in CAVD progression.
  • The model's agreement with clinical data validates its potential for further research and therapeutic development.