Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

579
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
579
Factors Influencing Drug Absorption: Drug Dissolution01:27

Factors Influencing Drug Absorption: Drug Dissolution

1.3K
The pharmacokinetic journey of drugs from solid oral dosage forms into systemic circulation is multifaceted. It begins with disintegration, a prerequisite ensuring a solid dosage form's subdivision into minute particles. Dissolution occurs next as these granulated entities solubilize in gastrointestinal fluids. This solubilization is crucial for the succeeding stage, permeation, which describes the traversal of the drug across the intestinal membrane and its subsequent entry into the blood...
1.3K
Factors Influencing Drug Absorption: Anatomical Parameters01:23

Factors Influencing Drug Absorption: Anatomical Parameters

690
Drug absorption involves the movement of drugs from the point of administration into the systemic circulation. Initially, Gastrointestinal (GI) motility propels the drug through the digestive tract and into the stomach. However, the stomach's high acidity and limited surface area restrict its role in drug absorption for most drugs. The drug then moves from the stomach to the small intestine via gastric emptying, which can be slowed by various factors, including interactions with other...
690
Factors Influencing Drug Absorption: Physicochemical Parameters01:22

Factors Influencing Drug Absorption: Physicochemical Parameters

1.0K
The physicochemical characteristics of drugs play a crucial role in formulating stable and bioavailable drug products. The solubility of a drug, governed by the varying pH along the GI tract and its dissociation constant (pKa), is pivotal in determining its ionization state and absorption rate. Notably, weak acids and bases remain unionized and are absorbed more rapidly.
Enhanced drug absorption can be achieved by reducing particle sizes and increasing surface areas, thereby facilitating...
1.0K
Drug Absorption: Overview01:17

Drug Absorption: Overview

2.1K
The process of drug absorption signifies the transition of a drug from its site of administration into the plasma. This process is influenced by various factors, including the route of administration, the anatomy of the absorption site, the mechanism of absorption, gut motility, and the drug's physicochemical properties.
When drugs are injected intravenously, they directly enter the systemic circulation. Alternatively, orally administered drugs navigate through the gastrointestinal (GI)...
2.1K
Drug Absorption: Factors Affecting GI Absorption01:19

Drug Absorption: Factors Affecting GI Absorption

6.5K
The process of oral drug absorption can be influenced by several factors. Weakly acidic drugs tend to be absorbed more readily from the stomach due to their nonionized state. However, absorption may be less efficient in the upper intestine, where drugs are often ionized. Interestingly, despite the stomach's apparent advantage for drug absorption, its mucous layer can hinder diffusion. Its surface area is also smaller than the intestine's, which can further slow down the absorption rate.
6.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Post-bariatric surgery adherence to clinical pharmacist recommendations in the ambulatory-care setting: A 6-month post-surgery analysis.

Journal of the American Pharmacists Association : JAPhA·2026
Same author

Is Oral Semaglutide a Good Fit for Patients After Metabolic Bariatric Surgery? A Biopharmaceutical Mechanistic Perspective.

Pharmaceutics·2026
Same author

New Onset of Acne Associated With Dietary Supplements Post-Metabolic Bariatric Surgery: A Case Report and Review of the Literature.

Journal of pharmacy practice·2026
Same author

Synergistic Anticancer Effects of Vitamin D and Plant-Derived Compounds: Molecular Mechanisms, Therapeutic Potential, and Nanotechnology-Enabled Delivery Approaches.

International journal of molecular sciences·2026
Same author

Multi-Target Neuroprotective Effects of Flavonoid-Rich <i>Ficus benjamina</i> L. Leaf Extracts: Mitochondrial Modulation, Antioxidant Defense, and Retinal Ganglion Cell Survival In Vivo.

International journal of molecular sciences·2025
Same author

<i>Etrog Citron</i> (<i>Citrus medica</i>) as a Novel Source of Antiviral Agents: Overview of Its Bioactive Phytochemicals and Delivery Approaches.

Pharmaceutics·2025

Related Experiment Video

Updated: Feb 19, 2026

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
08:59

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

Published on: December 3, 2020

8.7K

Active intestinal drug absorption and the solubility-permeability interplay.

Daniel Porat1, Arik Dahan1

  • 1Department of Clinical Pharmacology, School of Pharmacy, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.

International Journal of Pharmaceutics
|November 6, 2017
PubMed
Summary

Solubility-enabling formulations can increase drug solubility and permeability by overcoming the solubility-permeability tradeoff. Understanding this interplay is key for developing effective oral drug delivery systems, especially for lipophilic drugs.

Keywords:
D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS)Efflux transportIntestinal absorptionP-glycoprotein (P-gp)Solubility-enabling formulationsSolubility-permeability interplay

More Related Videos

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
18:57

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers

Published on: October 17, 2013

47.4K
Canine Intestinal Organoids in a Dual-Chamber Permeable Support System
11:11

Canine Intestinal Organoids in a Dual-Chamber Permeable Support System

Published on: March 2, 2022

4.4K

Related Experiment Videos

Last Updated: Feb 19, 2026

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
08:59

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

Published on: December 3, 2020

8.7K
Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
18:57

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers

Published on: October 17, 2013

47.4K
Canine Intestinal Organoids in a Dual-Chamber Permeable Support System
11:11

Canine Intestinal Organoids in a Dual-Chamber Permeable Support System

Published on: March 2, 2022

4.4K

Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery
  • Physical Chemistry

Background:

  • The solubility-permeability interplay is crucial for oral drug absorption.
  • Traditional approaches may overlook the complex relationship between solubility and permeability.
  • Solubility-enabling formulations aim to enhance drug dissolution and absorption.

Purpose of the Study:

  • To review the current understanding of the solubility-permeability interplay in oral drug delivery.
  • To highlight the impact of solubility-enabling formulations on drug permeability.
  • To emphasize the role of active permeability mechanisms.

Main Methods:

  • Literature review of studies on solubility-permeability interplay.
  • Analysis of formulation components affecting both solubility and permeability.
  • Discussion of passive and active transport mechanisms.

Main Results:

  • Solubility-enabling formulations can increase apparent solubility, potentially decreasing passive permeability (solubility-permeability tradeoff).
  • Formulation excipients may inhibit efflux transporters, leading to increased apparent permeability.
  • Co-formulation of solubilizing and efflux-inhibiting properties can enhance both solubility and permeability.

Conclusions:

  • A comprehensive understanding of the solubility-permeability interplay is essential for rational formulation design.
  • Intelligent formulation development can leverage excipient properties to optimize both solubility and permeability.
  • Effective solubility-enabling formulations can improve oral delivery of challenging drugs, including BCS Class IV compounds.