The hypothalamic-pituitary-thyroid axis and personality in a sample of healthy subjects

Thyroid hormones influence various brain pathologies, including psychiatric disorders. However, the relationship between these hormones and the psychological state in the normal, non-clinical population is poorly understood. We aimed to test whether serum levels of thyroid hormones are associated with personality in the healthy population. Thyrotropin (TSH), free T3 (FT4), total and free T4 (TT4 and FT4) concentrations were measured in the blood of 104 healthy participants (44% men) aged 18-59 (M=35±9). Personality traits were assessed using the revised short versions of the Temperament and Character Inventory (TCI-140) and the NEO Five-Factor Inventory (NEO-FFI). The data were analysed by correlational, regression, extreme groups and graphical techniques, which showed significant correlations between inter-individual variations in serum thyroid hormone levels and specific aspects of personality. In particular, high serum TSH was strongly associated with higher Persistence and Self-Directedness, and negatively correlated with Harm Avoidance on the TCI-140 and Neuroticism on the NEO-FFI, thus representing a more adaptive personality profile. Furthermore, increased FT4 was associated with lower Reward-Dependence, and increased TT4 was associated with lower Cooperativeness, representing a deficit in social attachment. Our data indicate that the relationship between thyroid hormones and personality in the healthy population might be rather more complex than the results obtained in clinical samples suggest.