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Pineocytomas.

A Disclafani1, R J Hudgins, M S Edwards

  • 1Department of Neurological Surgery, School of Medicine, University of California, San Francisco.

Cancer
|January 15, 1989
PubMed
Summary
This summary is machine-generated.

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Focal radiation therapy is effective for pineocytoma, with most patients showing no evidence of disease. Craniospinal radiation is only recommended if tumor dissemination is confirmed.

Area of Science:

  • Neuro-oncology
  • Radiation Oncology

Background:

  • Pineocytoma is a rare primary brain tumor originating in the pineal gland.
  • Optimal treatment strategies for pineocytoma require further investigation.

Purpose of the Study:

  • To report outcomes of histologically proven pineocytoma cases treated with focal radiation therapy.
  • To evaluate the efficacy of focal versus craniospinal radiation for pineocytoma management.

Main Methods:

  • Retrospective case series of six patients with pineocytoma.
  • Diagnosis confirmed by surgery or autopsy.
  • All patients received focal radiation therapy (4500-5400 cGy).
  • Post-treatment follow-up for recurrence and survival.

Main Results:

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  • Three patients remain alive with no evidence of disease at 21+, 52+, and 84+ months.
  • Two patients experienced local recurrence and died of tumor.
  • One patient died of Alzheimer's disease; another had tumor dissemination after local recurrence.
  • No recurrence outside the irradiated field was observed without initial local recurrence.

Conclusions:

  • Focal radiation therapy is a viable treatment for localized pineocytoma.
  • Postoperative staging is recommended for all pineocytoma patients.
  • Craniospinal radiation therapy is indicated only when tumor dissemination is documented.