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Dasatinib-induced Seborrheic Dermatitis-like Eruption

Ryan R Riahi1, Philip R Cohen1

  • 1Dr. Riahi is with DermSurgery Associates, Houston, Texas.

The Journal of Clinical and Aesthetic Dermatology
|November 7, 2017
PubMed

Insights

Dasatinib, used for chronic myelogenous leukemia, can cause seborrheic dermatitis-like skin issues. This case highlights a patient with melanoma experiencing this side effect during dasatinib treatment.

Area of Science:

  • Oncology
  • Dermatology

Background:

  • Dasatinib is a tyrosine kinase inhibitor approved for imatinib-resistant chronic myelogenous leukemia.
  • It is also explored for treating other cancers like non-small-cell lung cancer and melanoma.
  • Mucocutaneous side effects, such as seborrheic dermatitis, are common with antitumor agents.

Observation:

  • A 79-year-old woman with a history of sinonasal melanoma developed a seborrheic dermatitis-like eruption.
  • The patient was undergoing treatment with dasatinib.

Findings:

  • The case report details a patient experiencing a seborrheic dermatitis-like eruption while on dasatinib therapy.
  • The study reviews molecular abnormalities in melanoma and the mucocutaneous side effects of dasatinib.
  • Other antineoplastic agents linked to seborrheic dermatitis-like eruptions are also identified.

Implications:

  • This case underscores the potential for dasatinib to induce seborrheic dermatitis-like reactions.
  • Understanding these side effects is crucial for managing patients undergoing tyrosine kinase inhibitor therapy.
  • Further research may elucidate the mechanisms behind these drug-induced dermatologic conditions.
Keywords:
AntineoplasticBRAFc-kitchemotherapycutaneousdasatinibmelanomamucocutaneousmucosalseborrheic dermatitisside effecttyrosine kinase inhibitors

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