Related Experiment Video

Updated: Feb 19, 2026

Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens
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Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens

Published on: February 6, 2017

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Death Receptors: New Opportunities in Cancer Therapy

V M Ukrainskaya1, A V Stepanov1,2, I S Glagoleva2

  • 1M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya Str., 16 /10, Russian Academy of Sciences, Moscow, 117997, Russia.

Acta Naturae
|November 7, 2017
PubMed

Insights

This review explores anticancer therapies targeting death receptors (DRs). Enhancing DR agonists

Area of Science:

  • Oncology
  • Molecular Biology
  • Immunology

Background:

  • Malignant cells express death receptors (DRs) that can be targeted for cancer therapy.
  • Understanding DR structure, function, and ligand interactions is crucial for therapeutic development.

Purpose of the Study:

  • To review current and emerging strategies for anticancer therapies focused on death receptors.
  • To analyze the development and comparative efficacy of novel death receptor agonists.

Main Methods:

  • Comprehensive literature review of death receptor agonists and their clinical evaluation.
  • Analysis of agonistic antibodies targeting DR4 and DR5 in various clinical trial phases.

Main Results:

  • Current research focuses on DR4 and DR5 agonistic antibodies, with several in clinical trials.
  • Comparative analysis highlights trends in death receptor agonist development.

Conclusions:

  • Improving death receptor agonist stability, solubility, and half-life is key for enhanced efficacy.
  • Overcoming tumor cell resistance and exploring combination therapies are essential for effective application.
Keywords:
DR4DR5TNFapoptosisdeath receptorstumor cells

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