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The UCSC Genome Browser database: 2018 update.
Jonathan Casper1, Ann S Zweig1, Chris Villarreal1
1Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95064, USA.
Nucleic Acids Research
|November 7, 2017
Summary
The UCSC Genome Browser offers an updated web interface for exploring genome assemblies and annotation tracks. Recent enhancements include CRISPR/Cas9 support and improved variant analysis tools for researchers.
Area of Science:
- Genomics
- Bioinformatics
Background:
- The UCSC Genome Browser is a vital resource for exploring annotated genome assemblies.
- Continuous updates are essential for maintaining the relevance and utility of genomic databases.
Purpose of the Study:
- To report on recent updates and new features of the UCSC Genome Browser.
- To highlight improvements in data visualization and analysis tools for genomic research.
Main Methods:
- Web interface development and data integration.
- Implementation of new annotation tracks and analysis tools.
- User feedback incorporation for iterative improvements.
Main Results:
- Addition of 12 new genome assemblies and over 28 annotation tracks in the past year.
- Introduction of CRISPR/Cas9 guide sequence display and an interactive gene interaction navigator.
- Upgrades include a command-line Variant Annotation Integrator and enhanced highlighting capabilities.
Conclusions:
- The UCSC Genome Browser continues to evolve, providing researchers with cutting-edge tools for genome exploration.
- Recent updates enhance the browser's utility for diverse genomic analyses, including CRISPR applications and variant interpretation.
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