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Comorbidities in rosacea: A systematic review and update
Roger Haber1, Maria El Gemayel2
1Department of Dermatology, Saint George Hospital University Medical Center, Beirut, Lebanon; Faculty of Medicine, Balamand University, Lebanon.
Rosacea is linked to various systemic conditions, including cardiovascular and psychiatric diseases. Recognizing these comorbidities is crucial for effective patient screening and management.
Area of Science:
- Dermatology
- Internal Medicine
- Epidemiology
Background:
- Rosacea is characterized by cutaneous vascular abnormalities and inflammatory dysregulation.
- Emerging evidence links rosacea to cardiovascular, gastrointestinal, and psychiatric conditions, impacting patient morbidity and mortality.
Purpose of the Study:
- To systematically review and synthesize data on comorbidities associated with rosacea.
- To discuss the potential pathogenesis of these linked conditions.
- To guide the clinical evaluation of patients with rosacea.
Main Methods:
- A comprehensive literature search was conducted across PubMed/Medline, Embase, and Cochrane Collaboration databases.
- Included studies encompassed all publication dates, ages, sexes, and nationalities.
- Systematic review methodology was applied to analyze 29 selected studies.
Main Results:
- Significant associations were found between rosacea and depression, hypertension, cardiovascular diseases, anxiety, dyslipidemia, and diabetes mellitus.
- Other notable associations include migraine, rheumatoid arthritis, Helicobacter pylori infection, ulcerative colitis, and dementia.
- The review analyzed data from over 150,000 patients across various study designs.
Conclusions:
- Rosacea is demonstrably associated with a spectrum of systemic disorders.
- Early identification and management of these comorbidities are essential for comprehensive patient care.
- Further research is needed to elucidate the causal relationships.
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