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Related Concept Videos

Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...

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Related Experiment Video

Updated: Jul 2, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
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Rosacea and Migraine: A Systematic Review and Meta-Analysis Update.

Marina Mordehachvili Burlá1, Beatriz Ximenes Mendes2, Lucas Mendes Barbosa3

  • 1Department of Medicine, Estácio de Sá Vista Carioca University, Rio de Janeiro, Rio de Janeiro, Brazil.

International Journal of Dermatology
|September 3, 2025
PubMed
Summary
This summary is machine-generated.

Rosacea patients have a 25% migraine prevalence and nearly double the odds of migraine compared to those without rosacea. Further research is needed to understand influencing factors and improve treatment strategies.

Keywords:
associationepidemiologymigraineprevalencerosacea

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Area of Science:

  • Dermatology and Neurology
  • Epidemiology
  • Systematic Review and Meta-Analysis

Background:

  • The link between rosacea and migraine is established but poorly understood.
  • Emerging research suggests anti-migraine therapies may benefit rosacea patients.
  • This study provides updated insights into migraine prevalence within the rosacea population.

Purpose of the Study:

  • To systematically review and meta-analyze migraine prevalence in rosacea patients.
  • To compare migraine prevalence in rosacea patients versus non-rosacea populations.
  • To identify factors that may influence the association between rosacea and migraine.

Main Methods:

  • Adherence to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.
  • Inclusion of observational studies reporting migraine prevalence or odds ratios (ORs) in rosacea patients.
  • Random-effects model meta-analysis using R 4.4.1 with heterogeneity assessment (Cochran Q, I², PI, meta-regression).

Main Results:

  • 11 studies with 112,994 rosacea patients and 4,402,330 controls were analyzed.
  • Migraine prevalence in rosacea patients was 25% (95% CI, 0.15–0.35), with high heterogeneity (I²=99%).
  • Rosacea patients had nearly double the odds of migraine (OR=1.93, 95% CI, 1.42–2.64) compared to controls, with significant heterogeneity (I²=98%).

Conclusions:

  • High migraine prevalence and increased odds of migraine are observed in rosacea patients.
  • Substantial heterogeneity across studies necessitates further stratification for risk assessment.
  • Factors like subtype, gender, age, and severity may influence the association, requiring more research for definitive conclusions and improved treatment strategies.