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Updated: Feb 19, 2026

Transient Expression in Nicotiana Benthamiana Leaves for Triterpene Production at a Preparative Scale
Published on: August 16, 2018
Seco-dammarane triterpenoids from the leaves of Cyclocarya paliurus
Yan-Jiao Chen1, Liang Na2, Jialong Fan3
1TCM and Ethnomedicine Innovation & Development Laboratory, Sino-Pakistan TCM and Ethnomedicine Research Center, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, People's Republic of China.
Abstract:
The leaves of Cyclocarya paliurus with sweet taste are often used as herbal tea in People's Republic of China. In this study eight previously undescribed seco-dammarane type triterpenoids, cyclocariols A-H along with seven known compounds were isolated and characterized from its leaves. A possible biogenetic pathway for seco-dammarane type triterpenoids formation has been discussed. Cyclocariols A-H were evaluated for their cytotoxicities against human liver (SMMC-7721) and breast cancer (BT-549) cell lines. Cyclocariols A, B, E, and H were also tested against human colon tumor (HCT-116) cell lines, where all four exhibited good activities with IC50 values of 6.53, 4.94, 8.24, and 6.48 μM, respectively.
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