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Structure-based mechanistic insights into catalysis by small self-cleaving ribozymes

Aiming Ren1, Ronald Micura2, Dinshaw J Patel3

  • 1Life Sciences Institute, Zhejiang University, Hangzhou 310058, China.

Current Opinion in Chemical Biology
|November 7, 2017
PubMed
Summary

Small self-cleaving ribozymes are crucial for RNA replication. This review examines hammerhead, pistol, twister, and twister-sister ribozyme mechanisms, proposing structural studies of transition states to resolve catalytic pathway debates.

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