A novel device for improving visualization in an inadequately prepared colon.

Area of Science:

• Gastroenterology
• Medical Devices
• Animal Research

Background:

• Adequate bowel preparation is critical for colonoscopy quality, impacting procedure efficiency and diagnostic accuracy.
• Poor bowel preparation leads to increased procedure time, missed adenomas, higher costs, and decreased patient satisfaction.
• The Pure-Vu system is designed for intraprocedural colon cleansing, using irrigation and evacuation to manage inadequate prep.

Purpose of the Study:

• To evaluate the cleansing efficacy of the Pure-Vu system in animal models with inadequate bowel preparation.
• To assess the usability and safety of the Pure-Vu system during live animal colonoscopies.

Main Methods:

• The Pure-Vu system was utilized by four experienced gastroenterologists in 35 swine with intentionally reduced bowel preparation.
• Baseline bowel preparation was assessed, followed by colon cleansing with Pure-Vu, and subsequent reassessment.
• The system was attached to the colonoscope for intraprocedural use.

Main Results:

• No adverse events or procedure terminations were reported, indicating a favorable safety profile.
• Baseline adequate bowel preparation was achieved in 14% of swine, which improved to 100% after Pure-Vu use (p < .001).
• Physicians reported the Pure-Vu system as easy and intuitive to operate.

Conclusions:

• The Pure-Vu system demonstrated significant effectiveness in cleansing inadequately prepared swine colons.
• The device proved to be user-friendly and safe in the study.
• Clinical application of Pure-Vu may enhance overall colonoscopy prep quality and decrease the need for repeat procedures.