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A novel device for improving visualization in an inadequately prepared colon
Seth A Gross1, Lauren B Gerson2, Blair S Lewis3
1Tisch Hospital, NYU Langone Medical Center, New York, New York, USA.
Background And Aims:
Adequate bowel preparation is crucial for a quality colonoscopy. Poor bowel preparation can result in longer procedural times, missed adenomas, earlier repeat procedures, increase costs, and decreased patient satisfaction. Pure-Vu (MOTUS GI, Tirat Carmel, Israel) is a system that facilitates intraprocedural cleaning of a poorly prepared colon during a colonoscopy by irrigating the colon and evacuating the fluid and feces. The study aims were to evaluate Pure-Vu's cleansing capabilities and its usability and safety in a live animal colon.
Methods:
The Pure-Vu system was used by 4 experienced gastroenterologists in 35 Yorkshire cross swine (66% female) that received a reduced bowel preparation to ensure an inadequate bowel preparation at baseline. Before colonoscopy the Pure-Vu was attached to the colonoscope, and the baseline prep was assessed during insertion. The Pure-Vu system was then used to cleanse the colon and the prep then assessed after Pure-Vu use.
Results:
No adverse effects and no failed or prematurely terminated cases were noted. Fourteen percent of the swine colons were adequately prepped at baseline (median Boston Bowel Preparation Scale [BBPS] score = 0 [25th percentile = 0; 75th percentile = 1; interquartile range = 1]) and improved to 100% after use of Pure-Vu (Wilcoxon signed rank test P < .001) (median BBPS score = 3 [25th percentile = 3; 75th percentile = 3; interquartile range = 0]). The physicians found Pure-Vu easy and intuitive to operate.
Conclusions:
The Pure-Vu system effectively cleaned inadequately prepped swine colons and proved to be easy to use. The Pure-Vu device, applied in clinical practice, may result in improved overall prep quality and a reduction in repeat examinations because of inadequately prepped colons.
Insights
The Pure-Vu system effectively cleans poorly prepared colons during colonoscopy in animal models. This innovative device improves bowel prep quality, potentially reducing repeat procedures and enhancing patient outcomes.
Area of Science:
- Gastroenterology
- Medical Devices
- Animal Research
Background:
- Adequate bowel preparation is critical for colonoscopy quality, impacting procedure efficiency and diagnostic accuracy.
- Poor bowel preparation leads to increased procedure time, missed adenomas, higher costs, and decreased patient satisfaction.
- The Pure-Vu system is designed for intraprocedural colon cleansing, using irrigation and evacuation to manage inadequate prep.
Purpose of the Study:
- To evaluate the cleansing efficacy of the Pure-Vu system in animal models with inadequate bowel preparation.
- To assess the usability and safety of the Pure-Vu system during live animal colonoscopies.
Main Methods:
- The Pure-Vu system was utilized by four experienced gastroenterologists in 35 swine with intentionally reduced bowel preparation.
- Baseline bowel preparation was assessed, followed by colon cleansing with Pure-Vu, and subsequent reassessment.
- The system was attached to the colonoscope for intraprocedural use.
Main Results:
- No adverse events or procedure terminations were reported, indicating a favorable safety profile.
- Baseline adequate bowel preparation was achieved in 14% of swine, which improved to 100% after Pure-Vu use (p < .001).
- Physicians reported the Pure-Vu system as easy and intuitive to operate.
Conclusions:
- The Pure-Vu system demonstrated significant effectiveness in cleansing inadequately prepared swine colons.
- The device proved to be user-friendly and safe in the study.
- Clinical application of Pure-Vu may enhance overall colonoscopy prep quality and decrease the need for repeat procedures.
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