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Drug Release from Porous Matrixes based on Natural Polymers
Beata Kaczmarek1, Alina Sionkowska1
1Department of Chemistry of Biomaterials and Cosmetics, Faculty of Chemistry, Nicolaus Copernicus University in Torun, Torun. Poland.
Current Pharmaceutical Biotechnology
|November 8, 2017
Summary
Natural polymers offer advanced drug delivery systems, improving treatment efficiency and patient comfort. Modifications like cross-linking enhance their properties for controlled drug release applications.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Drug Delivery Systems
Background:
- Review of recent advances in drug release from natural polymer matrices.
- Discussion of properties of natural polymers like proteins and polysaccharides.
- Focus on collagen, elastin, chitosan, hyaluronic acid, and sodium alginate for drug delivery.
Purpose of the Study:
- To report on recent advances in drug release from natural polymer matrices.
- To discuss the properties and applications of various natural polymers in drug delivery.
- To highlight the advantages and challenges of using natural polymers in controlled release systems.
Main Methods:
- Literature review of scientific articles and practical work on natural polymer-based drug release.
- Analysis of drug release profiles from biopolymer matrices.
- Discussion of material properties, including biocompatibility, bioresorbability, and non-toxicity.
Main Results:
- Natural polymers possess advantageous properties like biocompatibility, bioresorbability, and non-toxicity.
- Common natural polymers such as collagen, elastin, chitosan, hyaluronic acid, and sodium alginate are suitable for drug delivery.
- Disadvantages like high solubility and low thermal stability necessitate cross-linking for improved performance.
Conclusions:
- Natural polymer matrices offer significant advantages for drug delivery, including targeted delivery and reduced toxicity.
- Controlled drug release from porous polymeric matrices relies on carrier degradation, dissolution, and diffusion.
- Careful selection of polymer matrix and optimization of drug release rates are crucial for effective medical treatment.
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