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Related Concept Videos

Disorders of Hemostasis01:24

Disorders of Hemostasis

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Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
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Related Experiment Video

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In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time
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Vascular diseases and bleedings.

Harald Hegen1, Michael Auer1, Florian Deisenhammer1

  • 1Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.

Handbook of Clinical Neurology
|November 8, 2017
PubMed
Summary

Cerebrospinal fluid (CSF) biomarkers are crucial for understanding central nervous system vascular diseases like stroke. Research is ongoing to find new CSF molecules for better diagnosis and patient care.

Keywords:
biomarkercerebral infarctioncerebral vasospasmcerebrospinal fluiddelayed cerebral ischemiaintracerebral hemorrhageischemic strokesubarachnoid hemorrhage

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Area of Science:

  • Neurology
  • Biochemistry
  • Biomarker Discovery

Background:

  • Central nervous system vascular diseases, including stroke, often involve hemorrhage or ischemia.
  • Cerebrospinal fluid (CSF) is a key body fluid for biomarker exploration in these neurological disorders.
  • Established CSF parameters exist for subarachnoid hemorrhage, but further biomarkers are needed.

Purpose of the Study:

  • To provide an overview of current knowledge on CSF biomarkers in spontaneous subarachnoid hemorrhage, spontaneous intracerebral hemorrhage, and ischemic stroke.
  • To discuss the role of CSF molecules in disease pathophysiology.
  • To explore the potential clinical applications of these biomarkers.

Main Methods:

  • Review of existing evidence on diagnostic tests for CSF biomarkers.
  • Discussion of the pathophysiological roles of various CSF molecules.
  • Analysis of methodological aspects and research limitations in the field.

Main Results:

  • Current diagnostic approaches for CSF biomarkers in stroke and related vascular CNS diseases were recapitulated.
  • The pathophysiological significance of various CSF molecules was discussed.
  • Potential future clinical applications were illuminated.

Conclusions:

  • There is a continued need for novel CSF biomarkers to enhance understanding and management of vascular central nervous system diseases.
  • Further research into CSF molecules can improve diagnostic accuracy and patient outcomes.
  • Addressing methodological challenges is essential for advancing CSF biomarker research.