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Author Spotlight: Overcoming Anti-VEGF Resistance Through Advanced Vascular Morphology Assessment in Choroidal Neovascularization
Published on: August 11, 2023
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Evolving multidimensional pharmacological approaches to CNV therapy in AMD
1a Institute of Drug Research, School of Pharmacy, Faculty of Medicine, Hadassah Ein Kerem Medical Campus , Hebrew University of Jerusalem , Jerusalem , Israel.
Current Eye Research
|November 8, 2017
Summary
New treatments combining anti-Vascular Endothelial Growth Factor agents with other drugs may improve outcomes for age-related macular degeneration by targeting multiple pathways to control choroidal neovascularization and reduce vision loss.
Area of Science:
- Ophthalmology
- Medical Research
Background:
- Age-related macular degeneration (AMD) is a leading cause of global vision loss.
- Current treatments using anti-Vascular Endothelial Growth Factor (VEGF) agents have shown initial success but face challenges like recurrence and complications.
Purpose of the Study:
- To review the current status of anti-VEGF therapy for AMD.
- To explore novel therapeutic targets beyond anti-VEGF for AMD treatment.
Main Methods:
- Literature review of studies on anti-VEGF agents in AMD.
- Discussion of emerging therapeutic strategies and targets.
Main Results:
- Vascular Endothelial Growth Factor (VEGF) is one of several factors driving choroidal neovascularization (CNV) in AMD.
- New strategies targeting downstream effectors of endothelial cell proliferation, like TNP-470, show promise for sustained CNV inactivation.
Conclusions:
- Combining anti-VEGF therapies with longer-acting, multi-target drugs like Methionine Aminopeptidase-2 inhibitors could offer more effective AMD management.
- Such combinations may better control CNV, prevent atrophy and fibrosis, and decrease the need for frequent intraocular injections.
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