Related Experiment Video

Updated: Feb 19, 2026

Studying Chronic Exposure of Mice to Ultraviolet B Radiation
03:20

Studying Chronic Exposure of Mice to Ultraviolet B Radiation

Published on: August 19, 2025

2.1K

Occupational UV-Exposure is a Major Risk Factor for Basal Cell Carcinoma: Results of the Population-Based

Jochen Schmitt1, Eva Haufe, Freya Trautmann

  • 1Center of Evidence-based Healthcare, University Hospital and Medical Faculty Carl Gustav Carus, TU Dresden, Germany (Dr Schmitt, Dr Haufe, Trautmann, Stange); Institute and Outpatient Clinics of Occupational and Social Medicine, Medical Faculty Carl Gustav Carus, TU Dresden, Germany (Drs Haufe, Andreas Seidler); Department of Dermatology, Dermatological Radiotherapy and Dermatohistopathology, Special Clinics Hornheide, Münster, Germany (Drs Schulze, Dugas-Breit); Department of Dermatology, University Hospital Jena, Jena, Germany (Drs Elsner, Gina); Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, Friedrich-Alexander-University, Erlangen-Nürnberg, Germany (Drs Drexler, Weistenhöfer); Department of Dermatology, University Allergy Center, Medical Faculty Carl Gustav Carus, TU Dresden, Germany (Drs Bauer, Bruhn); Institute of Occupational, Social and Environmental Medicine, University Medical Center, Johannes-Gutenberg University, Mainz, Germany (Dr Letzel); Department of Dermatology, Environmental Health and Health Theory, University of Osnabrück and Institute of Interdisciplinary Dermatological Prevention and Rehabilitation (iDerm) at the University of Osnabrück, Osnabrück, Germany (Dr John); Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (DGUV), Institute of Ruhr-University Bochum (IPA), Bochum, Germany (Drs Fartasch, Brüning); Department of Clinical Social Medicine, Occupational and Environmental Dermatology, University of Heidelberg, Heidelberg, Germany (Drs Bachmann, Diepgen); Department of Dermatology, University Medical Center, Johannes-Gutenberg University, Mainz, Germany (Dr Lang); Institute of Interdisciplinary Dermatological Prevention and Rehabilitation (iDerm) at the University of Osnabrück, Employer's Liability Insurance Association Clinics Hamburg, Hamburg, Germany (Dr Bonness); Department of Dermatology and Allergy, University Bonn, Bonn, Germany (Drs Allam, Grobe); Department of Radiation, Institute of Occupational Health and Safety of the German Social Accident Insurance (DGUV), Sankt Augustin, Germany (Westerhausen, Dr Wittlich); and Department of Dermatology, Experimental Photobiology, Medical Faculty Carl Gustav Carus, TU Dresden, Dresden, Germany (Knuschke).

Journal of Occupational and Environmental Medicine
|November 8, 2017
PubMed
Summary

High occupational ultraviolet (UV) exposure significantly increases basal cell carcinoma (BCC) risk. Nonoccupational UV exposure did not show an independent association with BCC development, highlighting the need for workplace UV protection.

More Related Videos

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model12:37

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Published on: September 7, 2013

18.8K
Determining the Toxicity of UV Radiation and Chemicals on Primary and Immortalized Human Corneal Epithelial Cells09:31

Determining the Toxicity of UV Radiation and Chemicals on Primary and Immortalized Human Corneal Epithelial Cells

Published on: July 22, 2021

2.6K

Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
6.2K
Mutations01:35

Mutations

Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
44.7K
Mutations01:39

Mutations

Overview
94.7K
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
8.2K
Pigmentation01:19

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
4.6K
Nucleotide Excision Repair01:38

Nucleotide Excision Repair

DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
5.3K