Pleiokomenines A and B: Dimeric Aspidofractinine Alkaloids Tethered with a Methylene Group
Elvis Otogo N'Nang Obiang1,2, Grégory Genta-Jouve3, Jean-François Gallard4
1Équipe "Pharmacognosie-Chimie des substances naturelles" BioCIS, Univ. Paris-Sud, CNRS, Université Paris-Saclay , 5 rue J.-B. Clément, 92290 Châtenay-Malabry, France.
Abstract:
Pleiokomenines A and B (1 and 2), first examples of dimeric aspidofractinine alkaloids linked by a methylene bridge, were isolated from the stem bark of Pleiocarpa mutica. Their structures were elucidated by a combination of spectroscopic analyses and semisynthetic derivatization of pleiocarpinine (3) and a formaldehyde equivalent mediated by scandium trifluoromethanesulfonate. Pleiokomenines A (1) and B (2) showed moderate antiplasmodial activities in the micromolar range against the FcB1 strain.
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