A Review of Best Practices for Intravenous Push Medication Administration

Janelle R Lenz1, Daniel D Degnan, John B Hertig

  • 1Eli Lilly and Company (Dr Lenz), Purdue University College of Pharmacy (Drs Degnan and Hertig), University of Michigan College of Pharmacy (Dr Stevenson), and Visante, Inc (Dr Stevenson). Janelle R. Lenz, PharmD, is internal liaison at Eli Lilly and Company, supporting field-based medical liaisons within the areas of neurodegeneration and pain. At the time of writing this article, Dr Lenz was completing a medication safety fellowship with the Purdue College of Pharmacy and Lilly. Daniel D. Degnan, PharmD, MS, CPPS, FASHP, is the senior project manager at the Center for Medication Safety Advancement at Purdue University College of Pharmacy. Previously, he spent 10 years as the medication safety officer at a large health system in Indiana. John B. Hertig, PharmD, MS, CPPS, is the associate director at the Center for Medication Safety Advancement at the Purdue University College of Pharmacy. He has professional interests in pharmacy practice health policy. He currently serves as a contributing editor for several quality and safety publications. James G. Stevenson, PharmD, FASHP, is a professor in the department of clinical pharmacy at the University of Michigan College of Pharmacy. He is also president of Visante, Inc, a medicines management consulting company. He served as chief pharmacy officer for the University of Michigan Health System for 15 years.

Related Concept Videos

Routes of Drug Administration: Parenteral01:25

Routes of Drug Administration: Parenteral

The administration of drugs via parenteral routes allows for direct drug introduction into the systemic circulation, resulting in high bioavailability because the medication bypasses the harsh conditions of the gastrointestinal tract and hepatic metabolism.
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
3.1K
Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices01:28

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...
30
One-Compartment Open Model for IV Bolus Administration: General Considerations01:19

One-Compartment Open Model for IV Bolus Administration: General Considerations

The one-compartment model is a pharmacokinetic tool that models the body as a single, uniform compartment, facilitating the understanding of drug distribution and elimination. This model is particularly beneficial for intravenous (IV) bolus administration, where the drug rapidly circulates throughout the body.
The drug's presence in the body is defined by an equation representing the difference between the rates of drug entry and exit. Key parameters—elimination rate constant,...
785
IV Infusion to Oral Dosing: Conversion Methods01:28

IV Infusion to Oral Dosing: Conversion Methods

The development of extended-release formulations has facilitated the transition from intravenous to oral medication, offering a more convenient and patient-friendly approach to drug administration. This transition, however, requires careful management to ensure that therapeutic drug levels are maintained, preserving efficacy and avoiding adverse effects. Understanding pharmacokinetic principles and dosage calculations is critical during this process.Pharmacokinetics of the...
28
Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
1.9K
Drug Accumulation During Multiple Dosing: Repetitive IV Injections01:21

Drug Accumulation During Multiple Dosing: Repetitive IV Injections

Calculating drug dosage and accumulation in multiple-dose regimens is crucial for achieving therapeutic efficacy while avoiding toxicity. This involves determining the plasma drug concentrations over time to optimize dosing schedules. The principle of superposition is fundamental in this process, allowing for the prediction of drug concentration in plasma following multiple doses based on single-dose data.The principle of superposition asserts that the plasma concentration-time curves from...
318