Incidence of Infusion Site Reactions in Peripheral Fosaprepitant Infusions
Sarah C Gonçalves1, Solange M Sanches, Camila T Bueno
1A.C. Camargo Cancer Center, São Paulo, Brazil. Sarah C. Gonçalves, MSc, RN, is a nurse coordinator at the AC Camargo Cancer Center in São Paulo, Brazil. Solange M. Sanches, MD, PhD, is head of the Clinical Oncology Department at the AC Camargo Cancer Center in São Paulo, Brazil. Camila T. Bueno, RN, is an oncology nurse in the Chemotherapy Center at the A.C. Camargo Cancer Center in São Paulo, Brazil. Diana L. Villela de Castro, PhD, RN, is a senior nurse in the Continuing Education Department at the A.C. Camargo Cancer Center in São Paulo, Brazil. Aline Damascena, MSc, BS, is a statistician at the A.C. Camargo Cancer Center in São Paulo, Brazil. Giseli R.C. Santos, RN, is a nurse coordinator in the Risk Management Department of the A.C. Camargo Cancer Center in São Paulo, Brazil.
Abstract:
Fosaprepitant is administered intravenously to treat chemotherapy-induced nausea and vomiting. To verify the incidence of infusion site reactions and the relationship among risk factors, a quantitative retrospective cohort study was undertaken. The study included patients seen between October 2013 and February 2014. Fifty-seven patients were included in the study, and there were 105 infusions among them. Infusion site reactions were identified in 42 (40%) cases. Risk factors identified by the study included age (P < .001), insertion at the back of the hand and wrist (P < .001), and first fosaprepitant administration (P < .001). The study found evidence of a higher incidence of infusion site reactions than was reported in the package insert.
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