Related Experiment Video
Updated: Feb 19, 2026
03:36
Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
865
CD109 expression is upregulated in penile squamous cell carcinoma
Fengyun Dong1, Jin Wang2,3, Yinghua Xu4
1Medical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong 250014, P.R. China.
Oncology Letters
|November 9, 2017
Summary
Cluster of differentiation (CD) 109, a cell surface glycoprotein, is significantly upregulated in penile squamous cell carcinoma (PSCC). This finding suggests CD109 may play a role in PSCC development and could be a future therapeutic target.
Area of Science:
- Oncology
- Cell Biology
- Molecular Pathology
Background:
- Cluster of differentiation (CD) 109 is a cell surface glycoprotein involved in cell signaling.
- CD109 expression is noted in various squamous cell carcinomas.
- Its role in penile squamous cell carcinoma (PSCC) remains largely unexplored.
Purpose of the Study:
- To investigate the expression and significance of CD109 in PSCC.
- To determine if CD109 is a potential biomarker or therapeutic target for PSCC.
Main Methods:
- Immunohistochemical analysis of CD109 expression in 45 PSCC tissue microarrays.
- Assessment of CD109 mRNA and protein levels in 3 fresh PSCC samples using RT-qPCR, Western blotting, and immunofluorescence.
Main Results:
- CD109 transcription and protein expression were significantly elevated in PSCC tissues compared to adjacent normal tissues.
- CD109 expression was localized to squamous cells within the tumors.
- No significant association was found between CD109 expression levels and the differentiation grade of PSCC.
Conclusions:
- CD109 expression is upregulated in PSCC, indicating a potential role in its pathogenesis.
- CD109 represents a promising candidate for a therapeutic target in penile squamous cell carcinoma.
