Related Experiment Video
Updated: Feb 19, 2026

Refined Murine Model of Idiopathic Pulmonary Fibrosis
Published on: June 17, 2025
Pleuroparenchymal Fibroelastosis With Long History of Asbestos and Silicon Exposure
Liyan Xu1, Negar Rassaei1, Carla Caruso1
11 Penn State Health Milton S. Hershey Medical Center, Hershey, PA, USA.
Abstract:
Pleuroparenchymal fibroelastosis (PPFE) is an uncommon interstitial lung disease. PPFE is characterized by fibroelastosis involving the pleura and subjacent parenchyma with a predominantly upper lobe distribution. While different possible environmental and familial etiologies have been postulated in the literature, the etiology of this disease remains essentially unclear and most cases are considered as idiopathic. In this report, we describe a rare case of PPFE with multiple lung lobe involvements and prolonged asbestos and silica exposure. Our goal is to investigate the exposure of asbestos and silica and try to identify their possible association with PPFE.
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