Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biofabrication in suspension media for tissue engineering and<i>in vitro</i>modelling.

Biofabrication·2025
Same author

Assessment of Lumbar Vertebrae L1-L7 and Proximal Femur Microstructure in Sheep as a Large Animal Model for Osteoporosis Research.

Biology·2025
Same author

Correction to "Mechanical and Biochemical Stimulation of 3D Multilayered Scaffolds for Tendon Tissue Engineering".

ACS biomaterials science & engineering·2025
Same author

Biofabrication in suspension media-a decade of advances.

Biofabrication·2025
Same author

Achilles tendinopathy.

Nature reviews. Disease primers·2025
Same author

Using Hybrid Nanoplatforms to Combine Traditional Anti-Inflammatory Drug Delivery with RNA-Based Therapeutics for Macrophage Reprograming.

International journal of molecular sciences·2024

Related Experiment Video

Updated: Feb 19, 2026

A Novel Tenorrhaphy Suture Technique with Tissue Engineered Collagen Graft to Repair Large Tendon Defects
06:36

A Novel Tenorrhaphy Suture Technique with Tissue Engineered Collagen Graft to Repair Large Tendon Defects

Published on: December 10, 2021

3.4K

Cell-laden composite suture threads for repairing damaged tendons.

Raquel Costa-Almeida1,2,3,4, Rui M A Domingues1,2, Afsoon Fallahi3,4,5

  • 13B's Research Group-Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Guimarães, Portugal.

Journal of Tissue Engineering and Regenerative Medicine
|November 9, 2017
PubMed
Summary

New composite suture threads loaded with cells promote tendon regeneration. This innovative approach aids tissue repair and could lead to better clinical outcomes for tendon injuries.

Keywords:
biotextilesbraidingcell-laden fibrescomposite suturestendon tissue engineeringtissue regeneration

More Related Videos

Using Q Suture to Enhance Resistance to Gap Formation and Tensile Strength of Repaired Flexor Tendons
10:32

Using Q Suture to Enhance Resistance to Gap Formation and Tensile Strength of Repaired Flexor Tendons

Published on: June 3, 2020

6.4K
Polytetrafluoroethylene PTFE as a Suture Material in Tendon Surgery
09:13

Polytetrafluoroethylene PTFE as a Suture Material in Tendon Surgery

Published on: October 6, 2022

4.2K

Related Experiment Videos

Last Updated: Feb 19, 2026

A Novel Tenorrhaphy Suture Technique with Tissue Engineered Collagen Graft to Repair Large Tendon Defects
06:36

A Novel Tenorrhaphy Suture Technique with Tissue Engineered Collagen Graft to Repair Large Tendon Defects

Published on: December 10, 2021

3.4K
Using Q Suture to Enhance Resistance to Gap Formation and Tensile Strength of Repaired Flexor Tendons
10:32

Using Q Suture to Enhance Resistance to Gap Formation and Tensile Strength of Repaired Flexor Tendons

Published on: June 3, 2020

6.4K
Polytetrafluoroethylene PTFE as a Suture Material in Tendon Surgery
09:13

Polytetrafluoroethylene PTFE as a Suture Material in Tendon Surgery

Published on: October 6, 2022

4.2K

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Tendon injuries are common in active adults, leading to poor healing and significant healthcare costs.
  • Current surgical repairs using suture threads have limitations in promoting true tissue regeneration.
  • Limited cellularity and vascularity of tendons hinder their natural regenerative capacity.

Purpose of the Study:

  • To develop novel composite suture threads for enhanced tendon regeneration.
  • To investigate the potential of cell-laden hydrogel-coated fibers for bridging tendon defects.
  • To engineer 3D constructs mimicking native tendon architecture and mechanical properties.

Main Methods:

  • Creation of composite suture threads coated with cell-laden hydrogel.
  • Encapsulation of human tendon-derived cells within the hydrogel.
  • Assessment of cell migration, alignment, gene expression, and matrix production.
  • Evaluation of engineered constructs for mimicking native tendon tissue.

Main Results:

  • Encapsulated cells successfully migrated and aligned on the suture threads.
  • Significant up-regulation of key tendon-related genes (scleraxis, tenascin C) and matrix remodeling genes (MMPs).
  • Cells produced a collagen-rich matrix, creating a micro-environment comparable to native tendon tissue.

Conclusions:

  • Composite suture threads with cell-laden hydrogels show promise for tendon tissue regeneration.
  • This technology can be used for surgical repair and engineering of tendon-like constructs.
  • The approach offers a potential solution to improve clinical outcomes for tendon injuries.