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Neuromodulation in multiple sclerosis.

Hesham Abboud1, Eddie Hill2, Junaid Siddiqui3

  • 1Multiple Sclerosis and Neuroimmunology Program, University Hospitals of Cleveland, Cleveland, OH, USA/School of Medicine, Case Western Reserve University, Cleveland, OH, USA/Neurology Department, Alexandria University, Alexandria, Egypt.

Multiple Sclerosis (Houndmills, Basingstoke, England)
|November 9, 2017
PubMed
Summary
This summary is machine-generated.

Neuromodulation offers promising functional restoration for multiple sclerosis (MS) patients by targeting neuronal pathways. Techniques like deep brain stimulation and spinal cord stimulation show potential for managing MS symptoms and improving quality of life.

Keywords:
BCIDBSFESNeuromodulationbaclofen pumpmultiple sclerosis

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Area of Science:

  • Neurology
  • Neurorehabilitation
  • Biomedical Engineering

Background:

  • Multiple sclerosis (MS) research has historically prioritized immune-modulating therapies.
  • Recent advances necessitate a shift towards functional restoration and neuromodulation in MS.
  • Neuromodulation involves targeted electrical or chemical stimulation/inhibition of neurons.

Purpose of the Study:

  • To review available neuromodulatory techniques for multiple sclerosis (MS).
  • To evaluate the evidence supporting the use of neuromodulation in MS symptom management and neurorehabilitation.

Main Methods:

  • Review of existing literature on neuromodulatory techniques applied to MS.
  • Analysis of preliminary research on specific interventions such as intrathecal baclofen pumps, functional electrical stimulation, deep brain stimulation, spinal cord stimulation, sacral neuromodulation, posterior tibial nerve stimulation, transcranial magnetic stimulation, and brain-computer interfaces.

Main Results:

  • Intrathecal baclofen pump and functional electrical stimulation show promise for spasticity and motor function.
  • Deep brain stimulation may alleviate MS-related tremor and trigeminal neuralgia.
  • Spinal cord stimulation, sacral neuromodulation, and posterior tibial nerve stimulation demonstrate efficacy for pain and bladder dysfunction.
  • Transcranial magnetic stimulation and brain-computer interfaces are emerging as potential tools for symptom mitigation and neurorehabilitation.

Conclusions:

  • Neuromodulation represents a significant area for advancing functional recovery in multiple sclerosis.
  • Evidence supports the use of various neuromodulatory techniques for specific MS symptoms.
  • Further research is warranted to fully explore the potential of neuromodulation in MS neurorehabilitation.