Related Experiment Video
Updated: Feb 19, 2026

Microelectrode Guided Implantation of Electrodes into the Subthalamic Nucleus of Rats for Long-term Deep Brain Stimulation
Published on: October 2, 2015
Deep brain stimulation: custom-made silicone-coated pulse-generator implantation after allergic reaction to generator
Judith Anthofer1, Andreas Herbst2, Annettte Janzen3,4
1Department of Neurosurgery, Medical Centre, University of Regensburg, Franz-Josef-Strauss Allee 11, 93053, Regensburg, Germany. judith.anthofer@ukr.de.
Abstract:
Deep brain stimulation for Parkinson's disease has become an established treatment option in recent years. The method and its application in clinical practice has proved to be safe and effective. Nevertheless, procedure-related and hardware-related complications occur. We present a rare case of a patient with an allergic reaction to the impulse generator. The patient suffered from delayed wound-healing deficits with several wound revisions and generator repositionings. After diagnosis of an allergic reaction to components of the generator, a custom-made silicon-coated model was implanted. Hereafter, no wound healing-deficit occurred throughout long-term follow-up. Allergic reaction to hardware components may lead to wound-healing deficits. In such cases, custom-made silicon-coated models may be an effective treatment option.

