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Bone Augmentation Using Allogeneic Bone Blocks With Recombinant Bone Morphogenetic Protein-2.

Craig M Misch1

  • 1Private Practice, Oral & Maxillofacial Surgery and Prosthodontics, Sarasota, FL; Clinical Associate Professor, Department of Periodontics and Prosthodontics, University of Florida School of Dentistry, Gainesville, FL.

Implant Dentistry
|November 9, 2017
PubMed
Summary
This summary is machine-generated.

Allogeneic bone blocks combined with recombinant bone morphogenetic protein-2/absorbable collagen sponge show promise for dental ridge augmentation. This approach may offer a viable alternative to titanium mesh, promoting successful bone graft incorporation and implant survival.

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Area of Science:

  • Oral and Maxillofacial Surgery
  • Regenerative Medicine
  • Biomaterials Science

Background:

  • Limitations of absorbable collagen sponge (ACS) necessitate alternative scaffolding for recombinant bone morphogenetic protein-2 (rhBMP-2) in ridge augmentation.
  • Allogeneic bone blocks are being explored as potential scaffolds in combination with rhBMP-2/ACS.

Purpose of the Study:

  • To evaluate the efficacy and incorporation of allogeneic block grafts with rhBMP-2/ACS for dental ridge augmentation.
  • To assess graft resorption, bone augmentation, and dental implant survival rates in patients treated with this combination therapy.

Main Methods:

  • A case series involving 21 patients who received 37 allogeneic block grafts with rhBMP-2/ACS.
  • Cone-beam computed tomography (CBCT) was used for pre- and post-treatment measurements of ridge dimensions.
  • Dental implants were placed after a 6-month healing period, with follow-up assessments.

Main Results:

  • CBCT revealed variable graft resorption (average 14.7% at point A, 6.67% at point B), with no significant difference between measurement points.
  • Significant horizontal augmentation gain at the crest (average 4.61 mm) was achieved.
  • Sixty dental implants were placed with a high survival rate of 98.3%, and no further failures were observed during follow-up (3-34 months).

Conclusions:

  • Allogeneic bone blocks, when used with rhBMP-2/ACS, appear to be a suitable alternative to titanium mesh for ridge augmentation.
  • The use of rhBMP-2/ACS may enhance the incorporation of allogeneic block grafts.
  • This regenerative approach demonstrates potential for successful dental implant placement following ridge augmentation.