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Synthesis and Bioconjugation of Thiol-Reactive Reagents for the Creation of Site-Selectively Modified Immunoconjugates
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Water-soluble and UV traceable isatoic anhydride-based reagents for bioconjugation
Adam Fessler1, Corey Garmon, Thomas Heavey
1Department of Chemistry, University of North Carolina at Charlotte, 9201 University City Blvd, Charlotte, NC 28223, USA. cogle@uncc.edu.
Organic & Biomolecular Chemistry
|November 10, 2017
Abstract:
Isatoic anhydride is elaborated to water soluble bioconjugation reagents that gives functionality and water solubility in one self-cleaning step. This new platform offers high atom economy with carbon dioxide being the only byproduct, and is shown to very quickly and efficiently label proteins in bicarbonate buffered solutions.
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