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Phase II trial of N-methylformamide in advanced renal cancer

J S Abrams1, N Tait, H Silva

  • 1University of Maryland Cancer Center, Department of Internal Medicine, Baltimore 21201.

American Journal of Clinical Oncology
|February 1, 1989
PubMed

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Methylation is a phase II biotransformation process involving the attachment of a methyl group to a substrate. Enzymes known as methyltransferases orchestrate this reaction.
The mechanism of methylation unfolds in two stages. The first stage sees a methyltransferase enzyme facilitating the transfer of a methyl group from S-adenosylmethionine (SAM) to the substrate, forming S-adenosylhomocysteine (SAH). The second stage involves further metabolism of SAH into homocysteine, which can be recycled...