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The poverty-related neglected diseases: Why basic research matters
1Texas Children's Hospital Center for Vaccine Development, National School of Tropical Medicine, Baylor College of Medicine, Houston, Texas, United States of America.
Plos Biology
|November 10, 2017
Summary
Basic science research for neglected tropical diseases (NTDs) and malaria is underfunded, hindering the development of new control tools. Expanding basic research is crucial for global health equity.
Area of Science:
- Global Health
- Infectious Diseases
- Parasitology
Background:
- Malaria and neglected tropical diseases (NTDs) cause significant mortality and disability worldwide.
- Preventive measures and translational research have yielded public health gains, but innovation is limited.
- Basic science research funding lags behind, creating a gap in developing novel control strategies.
Purpose of the Study:
- To highlight the urgent need for increased investment in basic science research for neglected diseases.
- To identify key areas in basic science that can drive innovation in disease control.
Main Methods:
- The study emphasizes the importance of expanding approaches in systems biology, immunology, ecology, evolution, mathematical biology, and functional/comparative OMICs.
- It advocates for the utilization of gene editing, diverse model organisms, and advanced sequencing techniques like single-cell combinatorial indexing RNA sequencing.
Main Results:
- Current funding models for neglected diseases do not adequately support foundational scientific discovery.
- There is a missed opportunity to develop a robust pipeline of innovative tools for parasitic and related diseases.
Conclusions:
- Expanded basic science research is essential to address the global burden of neglected diseases.
- Access to innovation for neglected diseases should be recognized as a fundamental human right.
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