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Human Ageing Genomic Resources: new and updated databases.

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Summary
This summary is machine-generated.

The Human Ageing Genomic Resources (HAGR) database provides curated data on ageing genes, animal longevity, dietary restriction, and longevity-associated drugs. This resource aids researchers in understanding human ageing genetics and biology.

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Area of Science:

  • Genomics
  • Geroscience
  • Bioinformatics

Background:

  • Human ageing is a complex biological process that is not yet fully understood.
  • The Human Ageing Genomic Resources (HAGR) was established over a decade ago to consolidate data and tools for ageing research.
  • Significant advancements in data collection and analysis necessitate updates to existing resources.

Purpose of the Study:

  • To present the updated functionalities and improvements of the Human Ageing Genomic Resources (HAGR).
  • To highlight the comprehensive nature of HAGR as a central hub for ageing-related data.
  • To facilitate research into the genetic and biological basis of human ageing.

Main Methods:

  • Consolidation of six core databases: GenAge, AnAge, GenDR, LongevityMap, DrugAge, and CellAge.
  • Manual curation of data by experts to ensure accuracy and quality.
  • Integration of cross-links to internal databases and external resources for comprehensive data retrieval.

Main Results:

  • HAGR now includes over 300 human ageing genes and over 2000 model organism ageing genes (GenAge).
  • Features over 4000 species in the animal ageing database (AnAge).
  • Contains extensive data on dietary restriction genes (GenDR), human longevity genetic studies (LongevityMap), ageing drugs (DrugAge), and cell senescence genes (CellAge).

Conclusions:

  • HAGR serves as a valuable, continuously updated resource for researchers studying the genomics and biology of ageing.
  • The integrated databases and tools within HAGR support diverse research avenues in geroscience.
  • The freely accessible online platform promotes collaborative and efficient ageing research.