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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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lncRNA - Long Non-coding RNAs02:39

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Non-LTR Retrotransposons03:18

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As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
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Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
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Lymphoid Cells and Tissues01:18

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Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
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Identification of RNAs Engaged in Direct RNA-RNA Interaction with a Long Non-Coding RNA
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Identification of RNAs Engaged in Direct RNA-RNA Interaction with a Long Non-Coding RNA

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Long noncoding RNA identification in lymphoma.

Gu Siyu1, Zou Linqing2, Kong Linling1

  • 1Department of Medicine, Nantong University, Nantong, Jiangsu 226001, PR China.

Future Oncology (London, England)
|November 11, 2017
PubMed
Summary
This summary is machine-generated.

Long noncoding RNA (lncRNA) show abnormal expression in lymphoma, impacting disease development. Detecting lncRNA offers potential as biomarkers for cancer diagnosis, prognosis, and therapeutic targets.

Keywords:
biomarkersdiagnosislncRNAlymphomaprognosistherapeutic targets

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Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Long noncoding RNAs (lncRNAs) are increasingly recognized for their roles in various biological processes.
  • Aberrant expression of lncRNAs has been implicated in the pathogenesis of numerous cancers, including lymphomas.
  • Understanding the specific lncRNAs involved in lymphoma is crucial for advancing diagnostic and therapeutic strategies.

Purpose of the Study:

  • To investigate the expression patterns of lncRNAs in lymphoma.
  • To evaluate the potential of lncRNAs as diagnostic and prognostic biomarkers for lymphoma.
  • To explore the therapeutic implications of targeting abnormally expressed lncRNAs in lymphoma.

Main Methods:

  • Analysis of lncRNA expression profiles in lymphoma patient samples.
  • Correlation analysis between lncRNA expression levels and clinical characteristics.
  • Assessment of lncRNAs as potential indicators for patient prognosis.

Main Results:

  • Significant abnormal expression of specific lncRNAs was detected in lymphoma.
  • lncRNA expression levels were found to be associated with patient clinical features.
  • Abnormal lncRNA expression demonstrated potential as a predictive marker for lymphoma prognosis.

Conclusions:

  • lncRNAs are key players in lymphoma pathogenesis due to their abnormal expression.
  • lncRNAs serve as promising biomarkers for lymphoma diagnosis and prognosis.
  • Targeting dysregulated lncRNAs presents a potential therapeutic avenue for lymphoma treatment.