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Updated: Feb 19, 2026

Analysis of Physiologic E-Selectin-Mediated Leukocyte Rolling on Microvascular Endothelium
Published on: February 11, 2009
Plasma irisin is elevated in type 2 diabetes and is associated with increased E-selectin levels
Karan S Rana1, Chathyan Pararasa1, Islam Afzal2
1Aston Research Centre for Healthy Ageing and School of Life and Health Sciences, Aston University, Birmingham, B4 7ET, UK.
Higher irisin hormone levels in type 2 diabetes (T2DM) patients correlate with obesity and endothelial dysfunction markers. This suggests irisin may be a therapeutic target for obesity and cardiovascular diabetes.
Area of Science:
- Endocrinology
- Metabolic disease research
- Cardiovascular health
Background:
- Irisin, a hormone released by muscle and fat tissue, influences energy expenditure and adipose tissue phenotype.
- Conflicting evidence exists regarding irisin levels in type 2 diabetes (T2DM).
Purpose of the Study:
- To investigate plasma irisin concentrations in T2DM patients.
- To assess associations between irisin and body composition, endothelial dysfunction, and telomere length.
Main Methods:
- Measured plasma irisin in 79 T2DM individuals.
- Analyzed correlations with body mass index, body fat percentage, HbA1c, soluble E-selectin, and visceral adiposity.
- Examined irisin's effect on endothelial cell gene expression.
Main Results:
- Plasma irisin levels were significantly higher in T2DM patients compared to healthy controls.
- Irisin positively correlated with BMI, body fat percentage, HbA1c, and soluble E-selectin.
- Irisin negatively correlated with visceral adiposity and predicted soluble E-selectin levels.
Conclusions:
- Elevated plasma irisin in T2DM is linked to adiposity and pro-atherogenic endothelial changes.
- Irisin may represent a novel therapeutic target for obesity and cardiovascular diabetes.
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