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CMR-based blood oximetry via multi-parametric estimation using multiple T2 measurements.

Juliet Varghese1, Lee C Potter2, Richard LaFountain3

  • 1Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, USA.

Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance
|November 11, 2017
PubMed
Summary

This study introduces a new non-invasive cardiac MRI method to measure blood oxygen saturation (O2 saturation) without calibration. The technique accurately estimates O2 saturation, offering a valuable tool for cardiovascular disease diagnosis.

Keywords:
Cardiovascular magnetic resonanceOxygen saturationT2 mapping

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Area of Science:

  • Cardiovascular Imaging
  • Medical Physics
  • Biomedical Engineering

Background:

  • Accurate blood oxygen saturation (O2 saturation) measurement is crucial for cardiovascular disease evaluation.
  • Current non-invasive methods for cardiac O2 saturation lack generalizability due to technique-specific calibration factors.
  • Existing T2-based cardiac magnetic resonance (CMR) oximetry methods require impractical patient-specific calibration.

Purpose of the Study:

  • To develop and validate a novel, non-invasive method for estimating blood oxygen saturation (O2 saturation) within the heart using CMR.
  • To overcome limitations of previous CMR oximetry techniques by eliminating the need for calibration factors.
  • To assess the accuracy of the proposed method against invasive measurements in a relevant physiological model.

Main Methods:

  • Utilized multiple T2 measurements with varying inter-echo pulse spacings (τ180) to acquire diverse data.
  • Jointly processed T2 values, hematocrit, and arterial O2 saturation within the Luz-Meiboom (L-M) model to estimate unknown parameters, including venous O2 saturation.
  • Validated the technique in a porcine model through progressive hypoxemia, comparing CMR-derived O2 saturation with invasive catheterization and a global calibration method.

Main Results:

  • The proposed CMR oximetry method demonstrated superior agreement (R² = 0.89) with invasive blood gas analysis compared to a global calibration method (R² = 0.73).
  • Quantitative T2 mapping-based oximetry provided more accurate venous O2 saturation estimates.
  • The technique successfully estimated O2 saturation in the right ventricle against a right atrial reference.

Conclusions:

  • A novel, non-invasive method for estimating blood oxygen saturation (O2 saturation) using quantitative T2 mapping has been successfully demonstrated.
  • This technique offers improved accuracy over existing calibration-dependent methods.
  • The developed CMR oximetry method holds potential as a valuable diagnostic tool for various cardiovascular conditions.