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A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
Published on: June 24, 2020
Inflammation and Autism: From Maternal Gut to Fetal Brain
Ivan Osokine1, Adrian Erlebacher1
1Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
Abstract:
Maternal immune activation (MIA) during pregnancy is associated with an increased risk of behavioral disorders in the offspring of affected mothers. Two recent studies highlight how maternal inflammation disrupts inhibitory interneuron networks and suggest that the maternal gut microbiome may be a contributing risk factor for MIA-induced behavioral abnormalities.
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