Multiorgan, Multimodality Imaging in Cardiometabolic Disease.

Area of Science:

• Multidisciplinary research integrating preclinical and clinical science.

Background:

• Cardiometabolic disease, encompassing obesity and type 2 diabetes mellitus, presents a substantial public health challenge.
• Excess cardiovascular risk is a common comorbidity.

Purpose of the Study:

• To provide a state-of-the-art, multimodality review of organ systems involved in cardiometabolic disease.
• To highlight potential targets for early intervention and therapeutic advancements.

Main Methods:

• Review of preclinical translational science findings.
• Analysis of advancements in in vivo diagnostic techniques.
• Multimodality perspective across multiple organ systems.

Main Results:

• Identification of potential intervention targets in various organ systems.
• Emphasis on the role of in vivo diagnostics in facilitating clinical translation.
• Comprehensive overview of the current landscape of cardiometabolic disease research.

Conclusions:

• Early intervention strategies targeting multiple organ systems are crucial.
• In vivo diagnostic techniques are key to validating and translating therapeutic advancements.
• A multimodality approach is essential for improving cardiometabolic health outcomes.