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Patterning Bioactive Proteins or Peptides on Hydrogel Using Photochemistry for Biological Applications
Published on: September 15, 2017
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Aptamer-functionalized hydrogel for self-programmed protein release via sequential photoreaction and hybridization.
Jinping Lai1, Pinliang Jiang1,2, Erin R Gaddes1
1Department of Biomedical Engineering, The Pennsylvania State University Pennsylvania 16802, USA.
Chemistry of Materials : a Publication of the American Chemical Society
|November 11, 2017
Summary
This study introduces a dynamic hydrogel that responds to light and molecular signals. It enables controlled protein release for applications like regulating cell migration.
Area of Science:
- Biomaterials Science
- Chemical Engineering
- Molecular Biology
Background:
- Hydrogels are versatile materials with tunable properties.
- Controlled release systems are crucial for biological and biomedical applications.
- Sequential signal response in materials remains a challenge.
Purpose of the Study:
- To develop a dynamic hydrogel with sequential response to physical and biomolecular signals.
- To create a self-programming platform for controlled bioactive substance release.
- To investigate the hydrogel's potential in regulating cell migration.
Main Methods:
- Photoreaction to activate and release an internal molecular signal.
- Hybridization reaction for biomolecular complex dissociation and protein release.
- Pulsatile light input to achieve periodical protein output.
Main Results:
- The hydrogel demonstrated sequential activation upon light stimulus.
- Released molecular signals acted as self-programming factors.
- Periodical protein release was achieved, influencing cell migration.
Conclusions:
- The developed hydrogel functions as a self-programming platform.
- It enables precise control over bioactive substance release.
- Potential applications in controlled drug delivery and tissue engineering.
