Paralytic ileus induced by glyphosate intoxication successfully treated using Kampo medicine

Area of Science:

• Toxicology
• Gastroenterology
• Pharmacology

Background:

• Glyphosate-surfactant herbicide ingestion can lead to severe systemic toxicity.
• Paralytic ileus is a serious gastrointestinal complication requiring effective management.

Observation:

• A 65-year-old female attempted suicide via glyphosate-surfactant herbicide ingestion.
• The patient developed multiple organ failure and paralytic ileus.
• Traditional Japanese Kampo medicines were administered sequentially: Daijokito, rikkunshito, and finally daikenchuto.

Findings:

• Daijokito addressed constipation and psychological symptoms.
• Rikkunshito was used to enhance gastric motility.
• Daikenchuto ultimately resolved all abdominal symptoms, including paralytic ileus.

Implications:

• Kampo medicines offer a potential therapeutic avenue for managing gastrointestinal dysfunction post-herbicide intoxication.
• Daikenchuto demonstrates efficacy in improving digestive peristalsis in complex clinical scenarios.
• This case highlights the complementary role of traditional medicine in conjunction with modern medical interventions for herbicide poisoning.