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Updated: Feb 19, 2026

SCAnED - An Open-source Skin Segmentation Macro for Semi-automated Cell and Nuclei Detection in Epidermal and Dermal Skin Compartments
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Psoriasis pathogenesis - Pso p27 constitutes a compact structure forming large aggregates.

Hilde Lysvand1, Ronny Helland2, Lars Hagen3

  • 1Department of Laboratory Medicine, Children's and Women's Health, Faculty of Medicine, Norwegian University of Science and Technology, NTNU, Postbox 8905, N-7491 Trondheim, Norway.

Biochemistry and Biophysics Reports
|November 11, 2017
PubMed
Summary

Psoriasis inflammation may involve an autoimmune reaction. A protein called Pso p27, generated in mast cells, forms aggregates that could play a role in the immune response to psoriasis.

Keywords:
AutoimmunityPso p27Pso p27-complexSCCA1SerpinB3X-ray crystallography

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Area of Science:

  • Immunology
  • Dermatology
  • Structural Biology

Background:

  • Psoriasis is a chronic inflammatory skin disease.
  • The autoimmune hypothesis for psoriasis suggests local antigen production.
  • Pso p27 protein is found in psoriatic plaques but not healthy skin.

Purpose of the Study:

  • To investigate the structure and aggregation of Pso p27.
  • To understand the potential immunogenic role of Pso p27 in psoriasis.

Main Methods:

  • X-ray crystallographic analysis of Pso p27 cleavage products.
  • Native gel electrophoresis to assess Pso p27 aggregation.

Main Results:

  • Pso p27 cleavage products form a complex structurally similar to SCCA1.
  • The Pso p27 complex features a reactive center loop inserted into a central β-sheet.
  • Native gel electrophoresis revealed that Pso p27 complexes form large aggregates.

Conclusions:

  • Pso p27 forms aggregates, suggesting a potential role in psoriasis immunogenicity.
  • The structural characteristics of Pso p27 complexes warrant further investigation in the context of autoimmune skin inflammation.