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Updated: Feb 19, 2026
12:17
Construction and Implantation of a Microinfusion System for Sustained Delivery of Neuroactive Agents.
Published on: March 17, 2008
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Implantable systems for drug delivery to the brain
Hemlata Kaurav1, Deepak N Kapoor1
1School of Pharmaceutical Sciences, Shoolini University of Biotechnology & Management Sciences, Solan 173212, H.P., India.
Therapeutic Delivery
|November 11, 2017
Summary
Implantable drug delivery systems offer sustained treatment for brain diseases. This review covers various implant types for continuous delivery, aiding conditions like glioblastomas and Alzheimer's disease.
Area of Science:
- Neuroscience
- Biomedical Engineering
- Pharmaceutics
Background:
- Brain diseases often necessitate long-term drug therapy.
- Consistent drug supply is crucial for managing neurological disorders.
- Current treatments face challenges in sustained drug delivery to the brain.
Purpose of the Study:
- To review various implantable drug delivery systems for the brain.
- To discuss their application in treating diverse neurological conditions.
- To highlight advancements in continuous drug administration for brain disorders.
Main Methods:
- Literature review of implantable drug delivery technologies.
- Categorization of systems including solid implants, in situ forming implants, microparticles, and depot formulations.
- Inclusion of polymeric-lipid implants and specific ester systems.
Main Results:
- Detailed discussion of multiple implantable systems for sustained brain drug delivery.
- Exploration of applications for glioblastomas, medulloblastoma, epilepsy, stroke, schizophrenia, and Alzheimer's diseases.
- Brief mention of implantable neural probes and microelectrode arrays.
Conclusions:
- Implantable systems are vital for long-term, continuous drug delivery in the brain.
- These systems offer promising therapeutic strategies for various brain diseases.
- Further research into implantable technologies can improve neurological disorder management.
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