Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Coffee consumption and digestive tract cancers.

C La Vecchia1, M Ferraroni, E Negri

  • 1Mario Negri Institute for Pharmacological Research, Milan, Italy.

Cancer Research
|February 15, 1989
PubMed
Summary

Coffee consumption shows no link to most digestive tract cancers. However, it appears to reduce the risk of colon and rectal cancers, possibly by affecting bile secretion.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Increased incidence of colon cancer among individuals younger than 50 years: A 17 years analysis from the cancer registry of the municipality of Milan, Italy.

Cancer epidemiology·2019
Same author

Consumers' role in mental health care: a research perspective.

Epidemiology and psychiatric sciences·2016
Same author

Metabolic syndrome and drug discontinuation in schizophrenia: a randomized trial comparing aripiprazole olanzapine and haloperidol.

Acta psychiatrica Scandinavica·2015
Same author

Vitamin E intake from natural sources and head and neck cancer risk: a pooled analysis in the International Head and Neck Cancer Epidemiology consortium.

British journal of cancer·2015
Same author

Lithium use from 2000 to 2010 in Italy: a population-based study.

Pharmacopsychiatry·2015
Same author

Nutrient-based dietary patterns and nasopharyngeal cancer: evidence from an exploratory factor analysis.

British journal of cancer·2014

Area of Science:

  • Gastroenterology
  • Oncology
  • Epidemiology

Background:

  • Digestive tract neoplasms represent a significant global health burden.
  • The role of dietary factors, including coffee consumption, in cancer risk remains an area of active research.
  • Previous studies have yielded inconsistent findings regarding coffee and digestive cancer risk.

Purpose of the Study:

  • To investigate the association between coffee consumption and the risk of various digestive tract neoplasms.
  • To analyze coffee's impact on cancers of the mouth, pharynx, esophagus, stomach, colon, rectum, liver, and pancreas.
  • To provide a comprehensive risk assessment pattern for digestive neoplasms in relation to coffee intake.

Main Methods:

  • A case-control study design was employed.

Related Experiment Videos

  • Involved 50 cases of mouth/pharynx cancer, 209 esophageal, 397 stomach, 455 colon, 295 rectal, 151 liver, 214 pancreatic cancers, and 1944 control subjects.
  • Multivariate analyses were used to assess relative risks associated with coffee consumption tertiles.

    • Main Results:

    • No significant association was found between coffee consumption and cancers of the mouth, pharynx, esophagus, stomach, liver, or pancreas.
    • A significant inverse trend in risk was observed for colon and rectal cancers with increasing coffee consumption.
    • Multivariate relative risks for upper tertiles of coffee consumption were 0.64 for colon and 0.66 for rectum.

    Conclusions:

    • Coffee consumption does not appear to increase the risk of most digestive tract cancers.
    • Coffee intake may offer a protective effect against colon and rectal cancers.
    • Potential mechanisms involve interference with bile secretion, reducing bile acid and sterol concentrations in the bowel.